日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Tau 单体和聚集体在人类神经元中的吸收和细胞内积累的独特调节

Amir T Marvian, Tabea Strauss, Qilin Tang, Benjamin J Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S Sutherland, William A McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F Lichtenthaler, Wo

The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology

型干扰素反应增强种子 tau 聚集并加剧 tau 病理

Sophie A I Sanford, Lauren V C Miller, Marina Vaysburd, Sophie Keeling, Benjamin J Tuck, Jessica Clark, Michal Neumann, Victoria Syanda, Leo C James, William A McEwan

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding

超分辨率成像揭示了接种后tau蛋白聚集体的自我复制过程

Eleni Dimou ,Taxiarchis Katsinelos ,Georg Meisl ,Benjamin J Tuck ,Sophie Keeling ,Annabel E Smith ,Eric Hidari ,Jeff Y L Lam ,Melanie Burke ,Sofia Lövestam ,Rohan T Ranasinghe ,William A McEwan ,David Klenerman

Cholesterol determines the cytosolic entry and seeded aggregation of tau

胆固醇决定 tau 进入细胞质并聚集

Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Tau 组装体在小鼠神经组织中并不表现得像独立作用的朊病毒样颗粒

Lauren V C Miller #, Aamir S Mukadam #, Claire S Durrant, Marina J Vaysburd, Taxiarchis Katsinelos, Benjamin J Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C James, Michael P Coleman, William A McEwan