日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis

TET2突变克隆性造血中先天免疫激活的代谢控制

Peter Geon Kim,Christopher B Hergott,Aidan P Miller,Amy Deik,Meaghan Boileau,Kevin Bullock,Kerry A Pierce,Angelina H Choy,Wesley Shin,Marie McConkey,Justin Loke,Birgitta A Ryback,Michael N Trinh,Justine C Rutter,Hong Yue,Hojong Yoon,Paul Park,Shourya S Roy Burman,Matthew G Vander Heiden,Eric S Fischer,Scott A Armstrong,Clary Clish,Benjamin L Ebert

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

异源三聚体蛋白复合物在质子梯度消散后组装成后生动物V-ATPase。

Christopher Nardone,Julian Mintseris,Dingwei He,Justine C Rutter,Benjamin L Ebert,Steven P Gygi,Tom Rapoport

The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect

p53错义变异体R248Q的半衰期延长,促进其积累并与野生型p53形成异源四聚体,从而发挥显性负效应。

Nancy Klemm,Roman R Schimmer,Nils K Konrad,Flavian Thelen,Jonas Fullin,Ebru Topçu,Christian Koch,Milena Treacy,Matthew Joseph Leventhal,Marco M Bühler,Veronika Lysenko,Alexandre P A Theocharides,Kari J Kurppa,Stefan Balabanov,Tuncay Baubec,Andrei V Krivtsov,Peter G Miller,Scott A Armstrong,Benjamin L Ebert,Markus G Manz,Cesar Nombela-Arrieta,Steffen Boettcher

Proteolysis-targeting chimeras with reduced off-targets

靶向蛋白水解的嵌合体,脱靶率较低

Tuan M Nguyen #, Vedagopuram Sreekanth #, Arghya Deb #, Praveen Kokkonda #, Praveen K Tiwari, Katherine A Donovan, Veronika Shoba, Santosh K Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary

Polymerization of ZBTB transcription factors regulates chromatin occupancy

ZBTB转录因子的聚合调控染色质占据

Paul M C Park,Jiho Park,Jared Brown,Moritz Hunkeler,Shourya S Roy Burman,Katherine A Donovan,Hojong Yoon,Radosław P Nowak,Mikołaj Słabicki,Benjamin L Ebert,Eric S Fischer

Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7

利用来那度胺控制的膜结合可降解IL-7对CAR-T细胞中的细胞因子信号传导进行化学遗传控制

Michael C Kann ,Emily M Schneider ,Antonio J Almazan ,Isabel C Lane ,Amanda A Bouffard ,Valentina M Supper ,Hana N Takei ,Alexander Tepper ,Mark B Leick ,Rebecca C Larson ,Benjamin L Ebert ,Marcela V Maus ,Max Jan

Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis

伴有髓系突变的急性淋巴细胞白血病是一种与克隆性造血相关的高危疾病

Caner Saygin ,Pu Zhang ,Jacob Stauber ,Ibrahim Aldoss ,Adam S Sperling ,Lachelle D Weeks ,Marlise R Luskin ,Todd C Knepper ,Pankhuri Wanjari ,Peng Wang ,Angela M Lager ,Carrie Fitzpatrick ,Jeremy P Segal ,Mehdi Gharghabi ,Sandeep Gurbuxani ,Girish Venkataraman ,Jason X Cheng ,Bart J Eisfelder ,Oliver Bohorquez ,Anand A Patel ,Sheethal Umesh Nagalakshmi ,Savita Jayaram ,Olatoyosi M Odenike ,Richard A Larson ,Lucy A Godley ,Daniel A Arber ,Christopher J Gibson ,Nikhil C Munshi ,Guido Marcucci ,Benjamin L Ebert ,John M Greally ,Ulrich Steidl ,Rosa Lapalombella ,Bijal D Shah # ,Wendy Stock #

Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells

靶向甲羟戊酸通路或Wnt通路以克服TP53突变型急性髓系白血病(AML)细胞的CAR-T细胞耐药性

Jan Mueller # ,Roman R Schimmer # ,Christian Koch ,Florin Schneiter ,Jonas Fullin ,Veronika Lysenko ,Christian Pellegrino ,Nancy Klemm ,Norman Russkamp ,Renier Myburgh ,Laura Volta ,Alexandre Pa Theocharides ,Kari J Kurppa ,Benjamin L Ebert ,Timm Schroeder ,Markus G Manz # ,Steffen Boettcher #

Discovery of electrophilic degraders that exploit SNAr chemistry

发现利用 SNAr 化学的亲电降解剂

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Brendan G Dwyer, Katherine A Donovan, Zixuan Jiang, Hannah M Jones, Dinah M Abeja, Meredith N Nix, Jianing Zhong, Mikołaj Słabicki, Eric S Fischer, Benjamin L Ebert, Nathanael S Gray

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

UBR5 在染色质上形成配体依赖性复合物,从而调节核激素受体的稳定性。

Jonathan M Tsai ,Jacob D Aguirre ,Yen-Der Li ,Jared Brown ,Vivian Focht ,Lukas Kater ,Georg Kempf ,Brittany Sandoval ,Stefan Schmitt ,Justine C Rutter ,Pius Galli ,Colby R Sandate ,Jevon A Cutler ,Charles Zou ,Katherine A Donovan ,Ryan J Lumpkin ,Simone Cavadini ,Paul M C Park ,Quinlan Sievers ,Charlie Hatton ,Elizabeth Ener ,Brandon D Regalado ,Micah T Sperling ,Mikołaj Słabicki ,Jeonghyeon Kim ,Rebecca Zon ,Zinan Zhang ,Peter G Miller ,Roger Belizaire ,Adam S Sperling ,Eric S Fischer ,Rafael Irizarry ,Scott A Armstrong ,Nicolas H Thomä ,Benjamin L Ebert