A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
雷帕霉素复合物 1/2 (mTORC1)/V-Akt 鼠胸腺瘤病毒致癌基因同源物 1 (AKT1)/组织蛋白酶 H 轴的机制靶点控制皮肤中的丝聚蛋白表达和加工，这是特应性皮炎患者皮肤屏障破坏的一种新机制
期刊:Journal of Allergy and Clinical Immunology
影响因子:11.4
doi:10.1016/j.jaci.2016.09.052
Aishath S Naeem, Cristina Tommasi, Christian Cole, Stuart J Brown, Yanan Zhu, Benjamin Way, Saffron A G Willis Owen, Miriam Moffatt, William O Cookson, John I Harper, Wei-Li Di, Sara J Brown, Thomas Reinheckel, Ryan F L O'Shaughnessy
信号转导
微生物学
肿瘤
皮肤癌
PI3K/Akt
mTOR
