日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct genetic architecture of gene and isoform level QTL in the Diversity Outbred (DO) mouse population

多样性近交系(DO)小鼠群体中基因和亚型水平QTL的独特遗传结构

Opara, Charles I; Mitok, Kelly A; Emfinger, Christopher H; Schueler, Katheryn L; Stapleton, Donnie S; Benkusky, Nancy A; Gardiparthi, Udaya; Willis, Kalynn H; Ruotti, Victor; Yandell, Brian S; Churchill, Gary A; Keller, Mark P; Attie, Alan D

A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

甲状旁腺激素/盐诱导激酶信号轴控制肾脏维生素 D 活化和生物体钙稳态

Sung-Hee Yoon, Mark B Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S Wang, Christian D Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B Sundberg, Ramnik J Xavier, Charles H Adelmann, Daniel J Brooks, Anthony

Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D3 in vivo

全基因组基因表达谱分析鉴定出参与体内骨骼对磷酸盐和1,25-二羟基维生素D3反应的关键基因和通路。

Seong Min Lee,Mark B Meyer,Nancy A Benkusky,J Wesley Pike

Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules

盐促激素和激酶SIK抑制引起的基因组快速变化,通过CREB模块驱动肾脏Cyp27b1和Cyp24a1的协同表达。

Mark B Meyer ,Nancy A Benkusky ,Seong Min Lee ,Sung-Hee Yoon ,Michael Mannstadt ,Marc N Wein ,J Wesley Pike

Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo

小鼠中假定的启动子近端 Tnfsf11 调控区域的删除不会改变体内骨量或 Tnfsf11 表达

Ryan S MacLeod, Mark B Meyer, Jinhu Xiong, Keisha M Cawley, Yu Liu, Melda Onal, Nancy A Benkusky, Jeff D Thostenson, J Wesley Pike, Charles A O'Brien

Genomic Mechanisms Governing Mineral Homeostasis and the Regulation and Maintenance of Vitamin D Metabolism

调控矿物质稳态及维生素D代谢调节和维持的基因组机制

Pike, J Wesley; Lee, Seong Min; Benkusky, Nancy A; Meyer, Mark B

A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues

基于染色质的机制控制肾脏和非肾脏组织中细胞色素 P450 基因 Cyp24a1 的差异调节

Mark B Meyer, Seong Min Lee, Alex H Carlson, Nancy A Benkusky, Martin Kaufmann, Glenville Jones, J Wesley Pike

Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse

靶向基因组缺失可识别多种增强子功能并产生肾脏特异性、内分泌缺陷的 Cyp27b1 假缺陷小鼠

Mark B Meyer, Nancy A Benkusky, Martin Kaufmann, Seong Min Lee, Robert R Redfield, Glenville Jones, J Wesley Pike

A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo

成纤维细胞生长因子23基因附近的控制区介导体内对磷酸盐、1,25(OH)2D3和LPS的反应

Lee, Seong Min; Carlson, Alex H; Onal, Melda; Benkusky, Nancy A; Meyer, Mark B; Pike, J Wesley

The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2

磷酸化雌激素受体 α (ER) 顺反组鉴定出一组富含直接 ER-DNA 结合和转录因子 GRHL2 的活性增强子

Kyle T Helzer, Mary Szatkowski Ozers, Mark B Meyer, Nancy A Benkusky, Natalia Solodin, Rebecca M Reese, Christopher L Warren, J Wesley Pike, Elaine T Alarid