日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A defective splicing machinery promotes senescence through MDM4 alternative splicing

缺陷的剪接机制通过 MDM4 替代剪接促进衰老

Mathieu Deschênes, Mathieu Durand, Marc-Alexandre Olivier, Alicia Pellerin-Viger, Francis Rodier, Benoit Chabot

The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA

双特异性激酶 DYRK1A 与乙肝病毒基因组相互作用并调节病毒 RNA 的产生

Florentin Pastor, Emilie Charles, Chiara Di Vona, Maëlys Chapelle, Michel Rivoire, Guillaume Passot, Benoit Chabot, Susana de la Luna, Julie Lucifora, David Durantel, Anna Salvetti

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine

迈向广谱抗病毒药物之路:SR激酶抑制剂哈尔明抑制HIV-1和冠状病毒复制

Subha Dahal ,Kiera Clayton ,Tyler Cabral ,Ran Cheng ,Shahrzad Jahanshahi ,Choudhary Ahmed ,Amrit Koirala ,Alonso Villasmil Ocando ,Ramy Malty ,Terek Been ,Javier Hernandez ,Maria Mangos ,David Shen ,Mohan Babu ,John Calarco ,Benoit Chabot ,Liliana Attisano ,Walid A Houry ,Alan Cochrane

The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress

转录因子 c-Jun 抑制 RBM39 在基因毒性应激期间重新编程前 mRNA 剪接

Florence Lemaitre, Fatima Chakrama, Tina O'Grady, Olivier Peulen, Gilles Rademaker, Adeline Deward, Benoit Chabot, Jacques Piette, Alain Colige, Charles Lambert, Franck Dequiedt, Yvette Habraken

The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma

SRSF10介导的包含外显子10的SREK1异常上调在人类肝细胞癌中发挥致癌驱动作用。

Cunjie Chang # ,Muthukumar Rajasekaran # ,Yiting Qiao # ,Heng Dong # ,Yu Wang ,Hongping Xia ,Amudha Deivasigamani ,Minjie Wu ,Karthik Sekar ,Hengjun Gao ,Mengqing Sun ,Yuqin Niu ,Qian Li ,Lin Tao ,Zhen Yan ,Menglan Wang ,Shasha Chen ,Shujuan Zhao ,Dajing Chen ,Lina Li ,Fan Yang ,Haojin Gao ,Baodong Chen ,Ling Su ,Liang Xu ,Ye Chen ,Veerabrahma Pratap Seshachalam ,Gongxing Chen ,Jayantha Gunaratne ,Wanjin Hong ,Junping Shi ,Gongying Chen ,David S Grierson ,Benoit Chabot ,Tian Xie ,Kam Man Hui ,Jianxiang Chen

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency

CLK SR激酶在控制HIV-1基因表达和潜伏期中发挥相反的作用

Subha Dahal ,Kiera Clayton ,Terek Been ,Raphaële Fernet-Brochu ,Alonso Villasmil Ocando ,Ahalya Balachandran ,Mikaël Poirier ,Rebecca Kaddis Maldonado ,Lulzim Shkreta ,Kayluz Frias Boligan ,Furkan Guvenc ,Fariha Rahman ,Donald Branch ,Brendan Bell ,Benoit Chabot ,Scott D Gray-Owen ,Leslie J Parent ,Alan Cochrane

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells

一类针对 SRSF10 并促进 p53 介导的人类结直肠癌细胞细胞毒性的新型抑制剂

Muhammad Sohail, Lulzim Shkreta, Johanne Toutant, Safwat Rabea, Jean-Philippe Babeu, Caroline Huard, Jasmin Coulombe-Huntington, Aurélie Delannoy, Morgane Placet, Sameh Geha, Fernand-Pierre Gendron, François Boudreau, Mike Tyers, David S Grierson, Benoit Chabot

NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay

NF45 和 NF90 通过与 Staufen 介导的 mRNA 衰变竞争来调节有丝分裂基因表达

Sami Nourreddine, Geneviève Lavoie, Justine Paradis, Khaled Ben El Kadhi, Antoine Méant, Léo Aubert, Benoit Grondin, Patrick Gendron, Benoit Chabot, Michel Bouvier, Sébastien Carreno, Philippe P Roux

hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage

hnRNP A1/A2 和 Sam68 与 SRSF10 协作控制对奥沙利铂介导的 DNA 损伤的替代剪接反应

Alexandre Cloutier, Lulzim Shkreta, Johanne Toutant, Mathieu Durand, Philippe Thibault, Benoit Chabot

Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication

一种新型化合物对 SRSF10 剪接调控功能的调节可损害 HIV-1 复制

Lulzim Shkreta, Marco Blanchette, Johanne Toutant, Emmanuelle Wilhelm, Brendan Bell, Benjamin A Story, Ahalya Balachandran, Alan Cochrane, Peter K Cheung, P Richard Harrigan, David S Grierson, Benoit Chabot