Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting
索拉非尼通过直接酶抑制和促进RET溶酶体降解（不依赖于蛋白酶体靶向）来强效抑制RET酪氨酸激酶活性。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.A110.119628
Fayyad-Kazan, Hussein; Rouas, Redouane; Merimi, Makram; El Zein, Nabil; Lewalle, Philippe; Jebbawi, Fadi; Mourtada, Mohamad; Badran, Hussein; Ezzeddine, Mohamad; Salaun, Bruno; Romero, Pedro; Burny, Arsène; Martiat, Philippe; Badran, Bassam; Berbey, Céline; Weiss, Norbert; Legrand, Claude; Allard, Bruno; Olson, Erin D; Nelson, Jennifer; Griffith, Katalyn; Nguyen, Thaothanh; Streeter, Michael; Wilson-Ashworth, Heather A; Gelb, Michael H; Judd, Allan M; Bell, John D; Plaza-Menacho, Iván; Mologni, Luca; Sala, Elisa; Gambacorti-Passerini, Carlo; Magee, Anthony I; Links, Thera P; Hofstra, Robert M W; Barford, David; Isacke, Clare M
