日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

CRISPR knockout screens reveal JUN as the master mediator of resistance to MAPK inhibition in KRAS-mutant pancreatic cancer

CRISPR基因敲除筛选揭示JUN是KRAS突变型胰腺癌中MAPK抑制剂耐药性的主要介质

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-025-03616-z
Mulero-Sánchez, Antonio; Bosma, Astrid; Visuvasam, Bonifiya; Pouliopoulou, Niki; van de Ven, Marieke; Proost, Natalie; Boeije, Manon; Lieftink, Cor; Beijersbergen, Roderick; Bernards, Rene; Mainardi, Sara
肿瘤
胰腺癌
肿瘤免疫
MAPK/ERK
JUN
RAS
发表日期：2026
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In Vivo Comparison of Intracameral and Intravitreal Implantation of a Timolol Maleate Miniaturized Injectable Delivery System Device

体内比较马来酸噻吗洛尔微型注射给药系统装置的房水内植入和玻璃体内植入效果

期刊:Ophthalmology Science
影响因子:4.6
doi:10.1016/j.xops.2025.100868
Ma, Chu Jian; Zhang, Youning; Bernards, Daniel A; Bloomer, Michele; Dickson, John; Rajadas, Jayakumar; Vyakarnam, Murty; Desai, Tejal A; Bhisitkul, Robert B
发表日期：2026
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Hepatocellular carcinoma: signaling pathways and therapeutic advances

肝细胞癌：信号通路和治疗进展

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-024-02075-w
Zheng, Jiaojiao; Wang, Siying; Xia, Lei; Sun, Zhen; Chan, Kui Ming; Bernards, René; Qin, Wenxin; Chen, Jinhong; Xia, Qiang; Jin, Haojie
信号转导
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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Implantation of engineered adipocytes suppresses tumor progression in cancer models.

植入工程化脂肪细胞可抑制癌症模型中的肿瘤进展

期刊:Nature Biotechnology
影响因子:41.7
doi:10.1038/s41587-024-02551-2
Nguyen Hai P, An Kelly, Ito Yusuke, Kharbikar Bhushan N, Sheng Rory, Paredes Breanna, Murray Elizabeth, Pham Kimberly, Bruck Michael, Zhou Xujia, Biellak Cassandra, Ushiki Aki, Nobuhara Mai, Fong Sarah L, Bernards Daniel A, Lynce Filipa, Dillon Deborah A, Magbanua Mark Jesus M, Huppert Laura A, Hammerlindl Heinz, Klein Jace Anton, Valdiviez Luis, Fiehn Oliver, Esserman Laura, Desai Tejal A, Yee Sook Wah, Rosenbluth Jennifer M, Ahituv Nadav
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies.

通过对线粒体依赖性的定量分析，可以预测衰老过程中的细胞凋亡启动，进而预测特定的衰老细胞清除

期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-024-01431-1
MacDonald Julie A, Bradshaw Gary A, Jochems Fleur, Bernards René, Letai Anthony
细胞生物学
Senescence
凋亡
线粒体
发表日期：2025
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Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state

ABT-263介导的衰老细胞清除作用与源自非衰老状态的癌细胞固有的凋亡依赖性相关

期刊:Cell Death and Differentiation
影响因子:13.7
doi:10.1038/s41418-024-01439-7
Fleur Jochems ，Chrysiida Baltira # ，Julie A MacDonald # ，Veerle Daniels ，Abhijeet Mathur ，Mark C de Gooijer ，Olaf van Tellingen ，Anthony Letai ，René Bernards
细胞生物学
肿瘤
T细胞
凋亡
发表日期：2025
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Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability

回复 Mishima 等人：MALT1 通过调节 GPX4 的稳定性来调控其表达。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2508813122
Wang, Jun; Liao, Long; Yang, Bo; Miao, Beiping; Bernards, René; Qin, Wenxin; Sun, Chong; Wang, Cun
信号转导
MALT1
GPX4
发表日期：2025
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CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma

CRISPR筛选发现ATPase VCP是胆管癌中一个可药物靶向的治疗弱点

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2519568122
Yang, Wu; Wang, Siying; Ji, Shuyi; Wang, Jian; Lian, Shuo; Li, Zhe; Jansen, Robin A; Wu, Wei; Niu, Kongyan; Sun, Zhen; Jia, Qi; Zheng, Jiaojiao; Zhu, Huijue; Deng, Xuan; Wang, Liqin; Fan, Zhoulong; Shi, Yaoping; Lieftink, Cor; Guan, Ming; Beijersbergen, Roderick L; Qin, Wenxin; Gao, Qiang; Bernards, René; Jin, Haojie
VCP
肿瘤
胆管癌
肿瘤免疫
发表日期：2025
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Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.

揭示 MALT1-RC3H1 轴在调节 GPX4 蛋白稳定性中的作用

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2419625121
Wang Jun, Liao Long, Miao Beiping, Yang Bo, Li Botai, Ma Xuhui, Fitz Annika, Wu Shanshan, He Jia, Zhang Qianqian, Ji Shuyi, Jin Guangzhi, Zhang Jianming, Cao Ying, Wang Hui, Qin Wenxin, Sun Chong, Bernards René, Wang Cun
其它
发表日期：2025
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Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial

阿特珠单抗联合贝伐珠单抗治疗微卫星不稳定性样转移性结直肠癌的疗效和安全性：一项多中心、单臂、II期、开放标签临床试验

期刊:ESMO Open
影响因子:8.3
doi:10.1016/j.esmoop.2025.105892
Elez, E; Siena, S; Sartore-Bianchi, A; Ros, J; Ciardello, F; Martinelli, E; Steeghs, N; Huijberts, S; Cervantes, A; Roselló, S; Tejpar, S; Wilmsen, B; Salazar, R; Santos, C; de Schaetzen, G; Muñoz, S; Bernards, R; Moreno, V; García-Galera, E; Alemany, R; Gros, A; Bardelli, A; Arena, S; Piris, A; Chavarría, E; Dienstmann, R; Tabernero, J
肿瘤
肠癌
肿瘤免疫
发表日期：2025
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