日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults

一项 I/IIa 期研究旨在评估 ChAdOx1-MVA 载体疫苗(表达一种新型肝期疟疾双抗原 LS2)在未感染过疟疾的成年人中通过孢子攻击的安全性、免疫原性和有效性。

Silman, Daniel; Flaxman, Amy; Datoo, Mehreen; Edwards, Nick J; Ramos-Lopez, Fernando; Mitton, Celia; Mair, Catherine; Bellamy, Duncan; Bowyer, Georgina; Morter, Richard; Halbroth, Benedict; Venkatraman, Navin; Folegatti, Pedro M; Marshall, Julia; Poulton, Ian; Bajer, Amelia; Salman, Ahmed M; Berrie, Eleanor; Baum, Jake; Blagborough, Andrew M; Crocker, Wendy; Roberts, Rachel; Lawrie, Alison M; Spencer, Alexandra J; Gilbert, Sarah C; Ewer, Katie J; Hill, Adrian V S

Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

作者更正:SARS-CoV-2疫苗ChAdOx1 nCoV-19加强剂的1/2期临床试验可诱导多功能抗体反应

Barrett, Jordan R; Belij-Rammerstorfer, Sandra; Dold, Christina; Ewer, Katie J; Folegatti, Pedro M; Gilbride, Ciaran; Halkerston, Rachel; Hill, Jennifer; Jenkin, Daniel; Stockdale, Lisa; Verheul, Marije K; Aley, Parvinder K; Angus, Brian; Bellamy, Duncan; Berrie, Eleanor; Bibi, Sagida; Bittaye, Mustapha; Carroll, Miles W; Cavell, Breeze; Clutterbuck, Elizabeth A; Edwards, Nick; Flaxman, Amy; Fuskova, Michelle; Gorringe, Andrew; Hallis, Bassam; Kerridge, Simon; Lawrie, Alison M; Linder, Aline; Liu, Xinxue; Madhavan, Meera; Makinson, Rebecca; Mellors, Jack; Minassian, Angela; Moore, Maria; Mujadidi, Yama; Plested, Emma; Poulton, Ian; Ramasamy, Maheshi N; Robinson, Hannah; Rollier, Christine S; Song, Rinn; Snape, Matthew D; Tarrant, Richard; Taylor, Stephen; Thomas, Kelly M; Voysey, Merryn; Watson, Marion E E; Wright, Daniel; Douglas, Alexander D; Green, Catherine M; Hill, Adrian V S; Lambe, Teresa; Gilbert, Sarah; Pollard, Andrew J

Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial

ChAd63/MVA Pfs25-IMX313 在 I 期首次人体试验中的安全性和免疫原性

de Graaf, Hans; Payne, Ruth O; Taylor, Iona; Miura, Kazutoyo; Long, Carol A; Elias, Sean C; Zaric, Marija; Minassian, Angela M; Silk, Sarah E; Li, Lee; Poulton, Ian D; Baker, Megan; Draper, Simon J; Gbesemete, Diane; Brendish, Nathan J; Martins, Filipa; Marini, Arianna; Mekhaiel, David; Edwards, Nick J; Roberts, Rachel; Vekemans, Johan; Moyle, Sarah; Faust, Saul N; Berrie, Eleanor; Lawrie, Alison M; Hill, Fergal; Hill, Adrian V S; Biswas, Sumi

A three-antigen Plasmodium falciparum DNA prime-Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults

一种包含三种抗原的恶性疟原虫DNA启动-腺病毒加强免疫的疟疾疫苗方案优于两种抗原的方案,并且能够保护健康、未感染过疟疾的成年人免受可控的人类疟疾感染。

Sklar, Marvin J; Maiolatesi, Santina; Patterson, Noelle; Sedegah, Martha; Limbach, Keith; Teneza-Mora, Nimfa; Chuang, Ilin; Hollis-Perry, K Monique; Banania, Jo Glenna; Guzman, Ivelese; Ganeshan, Harini; Reyes, Sharina; Hollingdale, Michael R; Wong, Mimi; Lindstrom, Ashley; Reyes, Anatalio; Alcorta, Yolanda; Garver, Lindsey; Bankard, Kelli; Belmonte, Arnel; Belmonte, Maria; Huang, Jun; Gowda, Kalpana; Inoue, Sandra; Velasco, Rachel; Bergmann-Leitner, Elke; Hutter, Jack; Lee, Tida; Adams, Nehkonti; Chaudhury, Sidhartha; Hunt, Devin; Tamminga, Cindy; Berrie, Eleanor; Bellamy, Duncan; Bittaye, Mustapha; Ewer, Katie; Diggs, Carter; Soisson, Lorraine A; Lawrie, Alison; Hill, Adrian; Richie, Thomas L; Villasante, Eileen; Epstein, Judith E; Duplessis, Christopher A

Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial.

中东呼吸综合征冠状病毒病毒载体候选疫苗的安全性和免疫原性:剂量递增、开放标签、非随机、非对照的 1 期试验

Folegatti Pedro M, Bittaye Mustapha, Flaxman Amy, Lopez Fernando Ramos, Bellamy Duncan, Kupke Alexandra, Mair Catherine, Makinson Rebecca, Sheridan Jonathan, Rohde Cornelius, Halwe Sandro, Jeong Yuji, Park Young-Shin, Kim Jae-Ouk, Song Manki, Boyd Amy, Tran Nguyen, Silman Daniel, Poulton Ian, Datoo Mehreen, Marshall Julia, Themistocleous Yrene, Lawrie Alison, Roberts Rachel, Berrie Eleanor, Becker Stephan, Lambe Teresa, Hill Adrian, Ewer Katie, Gilbert Sarah

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies

针对间日疟原虫杜菲结合蛋白的人类疫苗可诱导产生跨株抗体

Payne, Ruth O; Silk, Sarah E; Elias, Sean C; Milne, Kathryn H; Rawlinson, Thomas A; Llewellyn, David; Shakri, A Rushdi; Jin, Jing; Labbé, Geneviève M; Edwards, Nick J; Poulton, Ian D; Roberts, Rachel; Farid, Ryan; Jørgensen, Thomas; Alanine, Daniel Gw; de Cassan, Simone C; Higgins, Matthew K; Otto, Thomas D; McCarthy, James S; de Jongh, Willem A; Nicosia, Alfredo; Moyle, Sarah; Hill, Adrian Vs; Berrie, Eleanor; Chitnis, Chetan E; Lawrie, Alison M; Draper, Simon J

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

针对RH5的人类疫苗接种可诱导产生中和性抗疟抗体,从而抑制RH5入侵复合物的相互作用。

Payne, Ruth O; Silk, Sarah E; Elias, Sean C; Miura, Kazutoyo; Diouf, Ababacar; Galaway, Francis; de Graaf, Hans; Brendish, Nathan J; Poulton, Ian D; Griffiths, Oliver J; Edwards, Nick J; Jin, Jing; Labbé, Geneviève M; Alanine, Daniel Gw; Siani, Loredana; Di Marco, Stefania; Roberts, Rachel; Green, Nicky; Berrie, Eleanor; Ishizuka, Andrew S; Nielsen, Carolyn M; Bardelli, Martino; Partey, Frederica D; Ofori, Michael F; Barfod, Lea; Wambua, Juliana; Murungi, Linda M; Osier, Faith H; Biswas, Sumi; McCarthy, James S; Minassian, Angela M; Ashfield, Rebecca; Viebig, Nicola K; Nugent, Fay L; Douglas, Alexander D; Vekemans, Johan; Wright, Gavin J; Faust, Saul N; Hill, Adrian Vs; Long, Carole A; Lawrie, Alison M; Draper, Simon J

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

一种经MVA加强的单价黑猩猩腺病毒埃博拉疫苗

Ewer, Katie; Rampling, Tommy; Venkatraman, Navin; Bowyer, Georgina; Wright, Danny; Lambe, Teresa; Imoukhuede, Egeruan B; Payne, Ruth; Fehling, Sarah Katharina; Strecker, Thomas; Biedenkopf, Nadine; Krähling, Verena; Tully, Claire M; Edwards, Nick J; Bentley, Emma M; Samuel, Dhanraj; Labbé, Geneviève; Jin, Jing; Gibani, Malick; Minhinnick, Alice; Wilkie, Morven; Poulton, Ian; Lella, Natalie; Roberts, Rachel; Hartnell, Felicity; Bliss, Carly; Sierra-Davidson, Kailan; Powlson, Jonathan; Berrie, Eleanor; Tedder, Richard; Roman, Francois; De Ryck, Iris; Nicosia, Alfredo; Sullivan, Nancy J; Stanley, Daphne A; Mbaya, Olivier T; Ledgerwood, Julie E; Schwartz, Richard M; Siani, Loredana; Colloca, Stefano; Folgori, Antonella; Di Marco, Stefania; Cortese, Riccardo; Wright, Edward; Becker, Stephan; Graham, Barney S; Koup, Richard A; Levine, Myron M; Volkmann, Ariane; Chaplin, Paul; Pollard, Andrew J; Draper, Simon J; Ballou, W Ripley; Lawrie, Alison; Gilbert, Sarah C; Hill, Adrian V S

Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals

评估表达环子孢子蛋白和ME-TRAP的ChAd63-MVA载体疫苗对未感染过疟疾的个体控制性人类疟疾感染的疗效

Hodgson, Susanne H; Ewer, Katie J; Bliss, Carly M; Edwards, Nick J; Rampling, Thomas; Anagnostou, Nicholas A; de Barra, Eoghan; Havelock, Tom; Bowyer, Georgina; Poulton, Ian D; de Cassan, Simone; Longley, Rhea; Illingworth, Joseph J; Douglas, Alexander D; Mange, Pooja B; Collins, Katharine A; Roberts, Rachel; Gerry, Stephen; Berrie, Eleanor; Moyle, Sarah; Colloca, Stefano; Cortese, Riccardo; Sinden, Robert E; Gilbert, Sarah C; Bejon, Philip; Lawrie, Alison M; Nicosia, Alfredo; Faust, Saul N; Hill, Adrian V S

Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations

将 ChAd63 和 MVA ME-TRAP 初免-加强免疫的免疫原性从疟疾未感染人群转化到疟疾流行人群

Kimani, Domtila; Jagne, Ya Jankey; Cox, Momodou; Kimani, Eva; Bliss, Carly M; Gitau, Evelyn; Ogwang, Caroline; Afolabi, Muhammed O; Bowyer, Georgina; Collins, Katharine A; Edwards, Nick; Hodgson, Susanne H; Duncan, Christopher J A; Spencer, Alexandra J; Knight, Miguel G; Drammeh, Abdoulie; Anagnostou, Nicholas A; Berrie, Eleanor; Moyle, Sarah; Gilbert, Sarah C; Soipei, Peninah; Okebe, Joseph; Colloca, Stefano; Cortese, Riccardo; Viebig, Nicola K; Roberts, Rachel; Lawrie, Alison M; Nicosia, Alfredo; Imoukhuede, Egeruan B; Bejon, Philip; Chilengi, Roma; Bojang, Kalifa; Flanagan, Katie L; Hill, Adrian V S; Urban, Britta C; Ewer, Katie J