日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004:一种首创的口服泛RAS抑制剂,在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性

Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Carstens, Julienne L; Foote, Jeremy B; Graff, Emily C; Fang, Yu-Hua D; Keeton, Adam B; Chen, Xi; Valiyaveettil, Jacob; Berry, Kristy L; Bae, Sejong; Akce, Mehmet; Gorman, Greg; Yoon, Karina J; Manne, Upender; Boyd, Michael R; Buchsbaum, Donald J; Azmi, Asfar S; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

Foote Jeremy B, Mattox Tyler E, Keeton Adam B, Chen Xi, Smith Forrest T, Berry Kristy, Holmes Thomas W, Wang Junwei, Huang Chung-Hui, Ward Antonio, Mitra Amit K, Ramirez-Alcantara Veronica, Hardy Cherlene, Fleten Karianne G, Flatmark Kjersti, Yoon Karina J, Sarvesh Sujith, Nagaraju Ganji P, Bandi Dhana Sekhar Reddy, Maxuitenko Yulia Y, Valiyaveettil Jacob, Carstens Julienne L, Buchsbaum Donald J, Yang Jennifer, Zhou Gang, Nurmemmedov Elmar, Babic Ivan, Gaponeko Vadim, Abdelkarim Hazem, Boyd Michael R, Gorman Greg, Manne Upender, Bae Sejong, El-Rayes Bassel F, Piazza Gary A

Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia.

高特异性免疫蛋白酶体抑制剂 M3258 可诱导 KMT2A::AFF1 驱动的急性淋巴细胞白血病中的蛋白毒性应激和细胞凋亡

Jenkins Tyler W, Fitzgerald Jacquelyn Elise, Park Jieun, Wilson Addison M, Berry Kristy L, Wong Keith S, Houry Walid A, Lee Irene, Maksimenko Andrey V, Panizzi Peter R, Maxuitenko Yulia Y, Loop Matthew Shane, Mitra Amit K, Kisselev Alexei F