日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR-based chemogenomic profiling reveals redox vulnerabilities to epigallocatechin-3-gallate and green tea polyphenol extract

基于 CRISPR 的化学基因组分析揭示了表没食子儿茶素-3-没食子酸酯和绿茶多酚提取物的氧化还原脆弱性

Akla, Naoufal; Boudah, Anes; Bertomeu, Thierry; Chatr-Aryamontri, Andrew; Desjarlais, Michel; Annabi, Borhane

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

化学-遗传相互作用矩阵揭示药物机制和遗传结构

Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Huard, Caroline; Chatr-Aryamontri, Andrew; St-Cyr, Daniel J; Sánchez-Osuna, María; Papadopoli, David; Normandin, Karine; Paydar, Mohammadjavad; McLaughlan, Shannon; St-Denis, Corinne; Zhang, Li; Say, Henry; Palou, Roger; Stark, Chris; Breitkreutz, Bobby-Joe; van der Sloot, Almer M; Manohar, Sandhya; Lavoie, Hugo; Borden, Katherine L B; Raught, Brian; D'Amours, Damien; Sicheri, Frank; Verreault, Alain; Mader, Sylvie; Meloche, Sylvain; Therrien, Marc; Thibault, Pierre; Wilhelm, Brian; Dirks, Peter B; Aitchison, John D; Patton, Elizabeth; King, Randall W; Roux, Philippe P; Sauvageau, Guy; Hoang, Trang; Marinier, Anne; Harrington, Lea; Kwok, Benjamin; Archambault, Vincent; Topisirovic, Ivan; Tyers, Mike

CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity

CDADC1 是一种脊椎动物特异性的 dCTP 脱氨酶,可代谢吉西他滨和地西他滨,从而防止细胞毒性。

Rodriguez, Marcelo M; Chatterjee, Debashree; Guerry, Johanna; Patenaude, Anne-Marie; Cohen, Charles C H; Bois, Therence; Larouche, Ariane; Ferreira, Silvana R; Bertomeu, Thierry; Chatr-Aryamontri, Andrew; Zhang, Li; Mader, Sylvie; Nislow, Corey; St-Jean, Guillaume; Guindon, Yvan; Zahn, Astrid; Di Noia, Javier M

Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts.

抑制伯基特淋巴瘤中的 RNA 解旋酶 DDX3X 可诱导氧化应激,并阻碍异种移植瘤的进展

Beauchemin Hugues, Dalloul Zeinab, Piskor Eva-Maria, Calderon Virginie, Chatr-Aryamontri Andrew, Bertomeu Thierry, Möröy Tarik

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition

支架蛋白PRR14L将PP2A-TACC3轴与有丝分裂的准确性和对MPS1抑制的敏感性联系起来。

Liu, Albert Z; Narkar, Akshay; Li, Keming; Bertomeu, Thierry; Johnson, Blake A; Coulombe-Huntington, Jasmin; Dong, Yi; Zhu, Jin; Tyers, Mike; Li, Rong

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

靶向毒性限制了 CDK11 抑制剂对 1p36 缺失癌症的疗效

Julian Linda, Crozier Lisa, Lukow Devon, Mishra Sanat, Swamy Aditi, Hagenson Ryan A, Sennhenn Peter, Sausville Erin L, Mendelson Brianna, Chuaqui Claudio, Qiao Lu, Vasudevan Anand, Lin Kuan-Ting, Bhatia Sonam, Bertomeu Thierry, Chatr-Aryamontri Andrew, Zhang Li, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Nottoli Timothy, Bai Suxia, Lakshmipathi Jayalakshmi, Muthusamy Viswanathan, Van Vranken Jonathan G, Gygi Steven P, Thompson Sarah L, Smith Joan C, Anderson Kendall, Shah Sanjana, Bindra Ranjit S, Akerman Martin, Spector David L, Krainer Adrian R, Sheltzer Jason M

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia

囊泡运输是急性髓系白血病中他汀类药物反应的关键决定因素。

Krosl, Jana; Bordeleau, Marie-Eve; Moison, Céline; MacRae, Tara; Boivin, Isabel; Mayotte, Nadine; Gracias, Deanne; Baccelli, Irène; Lavallée, Vincent-Philippe; Bisaillon, Richard; Lehnertz, Bernhard; Mendoza-Sanchez, Rodrigo; Ruel, Réjean; Bertomeu, Thierry; Coulombe-Huntington, Jasmin; Boucher, Geneviève; Noronha, Nandita; Pabst, Caroline; Tyers, Mike; Gendron, Patrick; Lemieux, Sébastien; Barabé, Frédéric; Marinier, Anne; Hébert, Josée; Sauvageau, Guy

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

一种新型p53调节因子C16ORF72/TAPR1可缓冲端粒酶抑制作用

Benslimane, Yahya; Sánchez-Osuna, María; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Henry, Danielle; Huard, Caroline; Bonneil, Éric; Thibault, Pierre; Tyers, Mike; Harrington, Lea

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

多种多聚泛素化途径共同维持着 cullin-RING 连接酶的强大功能。

Hill, Spencer; Reichermeier, Kurt; Scott, Daniel C; Samentar, Lorena; Coulombe-Huntington, Jasmin; Izzi, Luisa; Tang, Xiaojing; Ibarra, Rebeca; Bertomeu, Thierry; Moradian, Annie; Sweredoski, Michael J; Caberoy, Nora; Schulman, Brenda A; Sicheri, Frank; Tyers, Mike; Kleiger, Gary