日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells.

NANOG增强子的发现及其在人类胚胎干细胞自我更新和分化中的关键作用

Yan Jielin, Luo Renhe, Rosen Bess P, Liu Dingyu, Wong Wilfred, Leslie Christina S, Huangfu Danwei

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

平行基因组规模的 CRISPR-Cas9 筛选将人类多能干细胞身份与适应性区分开来

Bess P Rosen, Qing V Li, Hyein S Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R Damodaran, Hanuman T Kale, Samuel J Kaplan, Michael A Beer, Simone Sidoli, Danwei Huangfu

Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

动态网络引导的 CRISPRi 筛选可识别细胞状态转换期间 CTCF 环约束的非线性增强子基因调控活性

Renhe Luo, Jielin Yan, Jin Woo Oh, Wang Xi, Dustin Shigaki, Wilfred Wong, Hyein S Cho, Dylan Murphy, Ronald Cutler, Bess P Rosen, Julian Pulecio, Dapeng Yang, Rachel A Glenn, Tingxu Chen, Qing V Li, Thomas Vierbuchen, Simone Sidoli, Effie Apostolou, Danwei Huangfu, Michael A Beer

Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

动态网络引导的CRISPRi筛选揭示了CTCF环约束的非线性增强子-基因调控活性在细胞状态转变中的作用

Luo, Renhe; Yan, Jielin; Oh, Jin Woo; Xi, Wang; Shigaki, Dustin; Wong, Wilfred; Cho, Hyunwoo; Murphy, Dylan; Cutler, Ronald; Rosen, Bess P; Pulecio, Julian; Yang, Dapeng; Glenn, Rachel; Chen, Tingxu; Li, Qing V; Vierbuchen, Thomas; Sidoli, Simone; Apostolou, Effie; Huangfu, Danwei; Beer, Michael A

CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

CRISPR 筛选揭示了 HHEX 在胰腺谱系定型和可塑性限制中的核心要求

Dapeng Yang, Hyunwoo Cho, Zakieh Tayyebi, Abhijit Shukla, Renhe Luo, Gary Dixon, Valeria Ursu, Stephanie Stransky, Daniel M Tremmel, Sara D Sackett, Richard Koche, Samuel J Kaplan, Qing V Li, Jiwoon Park, Zengrong Zhu, Bess P Rosen, Julian Pulecio, Zhong-Dong Shi, Yaron Bram, Robert E Schwartz, Jon

QSER1 protects DNA methylation valleys from de novo methylation

QSER1保护DNA甲基化谷免受从头甲基化的影响

Dixon, Gary; Pan, Heng; Yang, Dapeng; Rosen, Bess P; Jashari, Therande; Verma, Nipun; Pulecio, Julian; Caspi, Inbal; Lee, Kihyun; Stransky, Stephanie; Glezer, Abigail; Liu, Chang; Rivas, Marco; Kumar, Ritu; Lan, Yahui; Torregroza, Ingrid; He, Chuan; Sidoli, Simone; Evans, Todd; Elemento, Olivier; Huangfu, Danwei

Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency

解码多能性:利用基因筛选探究多能性的获得、维持和消失

Li, Qing V; Rosen, Bess P; Huangfu, Danwei

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation

基因组规模筛选发现 JNK-JUN 信号通路是多能性退出和内胚层分化的障碍。

Qing V Li ,Gary Dixon ,Nipun Verma ,Bess P Rosen ,Miriam Gordillo ,Renhe Luo ,Chunlong Xu ,Qiong Wang ,Chew-Li Soh ,Dapeng Yang ,Miguel Crespo ,Abhijit Shukla ,Qing Xiang ,Friederike Dündar ,Paul Zumbo ,Matthew Witkin ,Richard Koche ,Doron Betel ,Shuibing Chen ,Joan Massagué ,Ralph Garippa ,Todd Evans ,Michael A Beer ,Danwei Huangfu

Glutamine independence is a selectable feature of pluripotent stem cells

谷氨酰胺独立性是多能干细胞的一个可选择的特征

Santosha A Vardhana, Paige K Arnold, Bess P Rosen, Yanyang Chen, Bryce W Carey, Danwei Huangfu, Carlos Carmona Fontaine, Craig B Thompson, Lydia W S Finley