Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
抑制组蛋白乙酰转移酶功能可通过抑制同源重组使 CREBBP/EP300 突变体放射增敏,从而可能获得功能增益
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-021-26570-8
Manish Kumar #, David Molkentine #, Jessica Molkentine #, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robe