日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

p16通过新型泛素依赖性信号级联抑制DNA损伤修复

David P Molkentine #, Jessica M Molkentine #, Kathleen A Bridges, David R Valdecanas, Annika Dhawan, Reshub Bahri, Andrew J Hefner, Manish Kumar, Liangpeng Yang, Mohamed Abdelhakiem, Phillip M Pifer, Vlad Sandulache, Aakash Sheth, Beth M Beadle, Howard D Thames, Kathryn A Mason, Curtis R Pickering, 

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

抑制组蛋白乙酰转移酶功能可通过抑制同源重组使 CREBBP/EP300 突变体放射增敏,从而可能获得功能增益

Manish Kumar #, David Molkentine #, Jessica Molkentine #, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robe

Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer

综合分析确定了与头颈癌放射抗性相关的新型 AXL-PI3 激酶-PD-L1 信号轴

Heath D Skinner, Uma Giri, Liang P Yang, Manish Kumar, Ying Liu, Michael D Story, Curtis R Pickering, Lauren A Byers, Michelle D Williams, Jing Wang, Li Shen, Suk Y Yoo, You Hong Fan, David P Molkentine, Beth M Beadle, Raymond E Meyn, Jeffrey N Myers, John V Heymach

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer

TP53 进化行动评分识别出与头颈癌生存率降低和远处转移增加相关的高风险突变

David M Neskey, Abdullah A Osman, Thomas J Ow, Panagiotis Katsonis, Thomas McDonald, Stephanie C Hicks, Teng-Kuei Hsu, Curtis R Pickering, Alexandra Ward, Ameeta Patel, John S Yordy, Heath D Skinner, Uma Giri, Daisuke Sano, Michael D Story, Beth M Beadle, Adel K El-Naggar, Merrill S Kies, William N