日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II

抗疟原虫蛋白酶体抑制剂的构效关系研究——第二部分

Zhang, Hao; Ginn, John; Zhan, Wenhu; Leung, Annie; Liu, Yi J; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Michino, Mayako; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J; Cooper, Roland A; Liverton, Nigel; Foley, Michael; Meinke, Peter T; Nathan, Carl F; Kirkman, Laura A; Lin, Gang

Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors

大环肽作为物种选择性抗疟蛋白酶体抑制剂的设计、合成和优化

Hao Zhang, John Ginn, Wenhu Zhan, Yi J Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T Meinke, Carl F Nathan, Laura A Kirkman, Gang Lin

Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice

在人源化小鼠中开发具有抗疟活性的高选择性恶性疟原虫蛋白酶体抑制剂

Zhan, Wenhu; Zhang, Hao; Ginn, John; Leung, Annie; Liu, Yi J; Michino, Mayako; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K; Lafuente-Monasterio, Maria Jose; Martinez-Martinez, Maria Santos; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J; Cooper, Roland A; Meinke, Peter T; Nathan, Carl F; Kirkman, Laura A; Lin, Gang

Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger

KDM5A PHD3指状结构域氟化芳香笼对三甲基赖氨酸的生物分子识别机制

Pieters, Bas J G E; Wuts, Maud H M; Poater, Jordi; Kumar, Kiran; White, Paul B; Kamps, Jos J A G; Sherman, Woody; Pruijn, Ger J M; Paton, Robert S; Beuming, Thijs; Bickelhaupt, F Matthias; Mecinović, Jasmin

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

小分子靶向MUSASHI RNA结合活性治疗急性髓系白血病

Gerard Minuesa ,Steven K Albanese ,Wei Xie ,Yaniv Kazansky ,Daniel Worroll ,Arthur Chow ,Alexandra Schurer ,Sun-Mi Park ,Christina Z Rotsides ,James Taggart ,Andrea Rizzi ,Levi N Naden ,Timothy Chou ,Saroj Gourkanti ,Daniel Cappel ,Maria C Passarelli ,Lauren Fairchild ,Carolina Adura ,J Fraser Glickman ,Jessica Schulman ,Christopher Famulare ,Minal Patel ,Joseph K Eibl ,Gregory M Ross ,Shibani Bhattacharya ,Derek S Tan ,Christina S Leslie ,Thijs Beuming ,Dinshaw J Patel ,Yehuda Goldgur ,John D Chodera ,Michael G Kharas

Predicting Binding Affinities for GPCR Ligands Using Free-Energy Perturbation

使用自由能扰动预测 GPCR 配体的结合亲和力

Eelke B Lenselink, Julien Louvel, Anna F Forti, Jacobus P D van Veldhoven, Henk de Vries, Thea Mulder-Krieger, Fiona M McRobb, Ana Negri, Joseph Goose, Robert Abel, Herman W T van Vlijmen, Lingle Wang, Edward Harder, Woody Sherman, Adriaan P IJzerman, Thijs Beuming

In search of novel ligands using a structure-based approach: a case study on the adenosine A2A receptor

使用基于结构的方法寻找新型配体:以腺苷 A2A 受体为例的研究

Eelke B Lenselink, Thijs Beuming, Corine van Veen, Arnault Massink, Woody Sherman, Herman W T van Vlijmen, Adriaan P IJzerman

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

胺能受体的晶体结构能告诉我们哪些关于设计亚型选择性配体的信息?

Michino, Mayako; Beuming, Thijs; Donthamsetti, Prashant; Newman, Amy Hauck; Javitch, Jonathan A; Shi, Lei

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

表观遗传读取蛋白识别三甲基赖氨酸的化学基础

Jos J A G Kamps, Jiaxin Huang, Jordi Poater, Chao Xu, Bas J G E Pieters, Aiping Dong, Jinrong Min, Woody Sherman, Thijs Beuming, F Matthias Bickelhaupt, Haitao Li, Jasmin Mecinović

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor

发现并表征一种抑制 β-arrestin 募集至 D2 多巴胺受体的 G 蛋白偏向激动剂

R Benjamin Free, Lani S Chun, Amy E Moritz, Brittney N Miller, Trevor B Doyle, Jennie L Conroy, Adrian Padron, Julie A Meade, Jingbo Xiao, Xin Hu, Andrés E Dulcey, Yang Han, Lihua Duan, Steve Titus, Melanie Bryant-Genevier, Elena Barnaeva, Marc Ferrer, Jonathan A Javitch, Thijs Beuming, Lei Shi, Noe