日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Kinetic Model of Antigen-Dependent IgG Oligomerization and Complement Binding

抗原依赖性IgG寡聚化和补体结合的动力学模型

Strasser, Jürgen; Frischauf, Nikolaus; Schustereder, Lukas; Karner, Andreas; Bosgra, Sieto; Labrijn, Aran F; Beurskens, Frank J; Preiner, Johannes

Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding

IgG亚类激活补体的能力取决于它们在抗原结合后发生寡聚化的能力。

Frischauf, Nikolaus; Strasser, Jürgen; Borg, Ellen G F; Labrijn, Aran F; Beurskens, Frank J; Preiner, Johannes

Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremia.

金黄色葡萄球菌菌血症期间循环人浆细胞的单细胞测序

Kerkman Priscilla F, de Vor Lisanne, van der Vaart Thomas W, Ten Doesschate Thijs, Muts Remy M, Depelteau Jamie S, Scheepmaker Lisette M, Ruyken Maartje, de Haas Carla J C, Aerts Piet C, Marijnissen Renoud J, Schuurman Janine, Beurskens Frank J, Gorlani Andrea, Bardoel Bart W, Rooijakkers Suzan H M

DuoHexaBody-CD37(®), a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

DuoHexaBody-CD37® 是一种新型双位点 CD37 抗体,具有增强的 Fc 介导的六聚化作用,有望成为 B 细胞恶性肿瘤的潜在治疗方法。

Oostindie, Simone C; van der Horst, Hilma J; Kil, Laurens P; Strumane, Kristin; Overdijk, Marije B; van den Brink, Edward N; van den Brakel, Jeroen H N; Rademaker, Hendrik J; van Kessel, Berris; van den Noort, Juliette; Chamuleau, Martine E D; Mutis, Tuna; Lindorfer, Margaret A; Taylor, Ronald P; Schuurman, Janine; Parren, Paul W H I; Beurskens, Frank J; Breij, Esther C W

Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7

绕过脂寡糖 (LOS) 的相变:利用庚糖 1 聚糖突变体建立淋球菌抗 LOS 单克隆抗体 2C7 的广泛疗效

Chakraborti, Srinjoy; Gulati, Sunita; Zheng, Bo; Beurskens, Frank J; Schuurman, Janine; Rice, Peter A; Ram, Sanjay

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

CD20和CD37抗体协同作用,通过Fc介导的聚集激活补体。

Oostindie, Simone C; van der Horst, Hilma J; Lindorfer, Margaret A; Cook, Erika M; Tupitza, Jillian C; Zent, Clive S; Burack, Richard; VanDerMeid, Karl R; Strumane, Kristin; Chamuleau, Martine E D; Mutis, Tuna; de Jong, Rob N; Schuurman, Janine; Breij, Esther C W; Beurskens, Frank J; Parren, Paul W H I; Taylor, Ronald P

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

在补体受限条件下,能与抗原有效结合并形成六聚体的抗体可诱导补体依赖性细胞毒性。

Cook, Erika M; Lindorfer, Margaret A; van der Horst, Hilma; Oostindie, Simone; Beurskens, Frank J; Schuurman, Janine; Zent, Clive S; Burack, Richard; Parren, Paul W H I; Taylor, Ronald P

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

伊布替尼干扰治疗性CD20抗体的细胞介导抗肿瘤活性:对联合治疗的启示

Da Roit, Fabio; Engelberts, Patrick J; Taylor, Ronald P; Breij, Esther C W; Gritti, Giuseppe; Rambaldi, Alessandro; Introna, Martino; Parren, Paul W H I; Beurskens, Frank J; Golay, Josée

Complement is activated by IgG hexamers assembled at the cell surface

补体由细胞表面组装的IgG六聚体激活。

Diebolder, Christoph A; Beurskens, Frank J; de Jong, Rob N; Koning, Roman I; Strumane, Kristin; Lindorfer, Margaret A; Voorhorst, Marleen; Ugurlar, Deniz; Rosati, Sara; Heck, Albert J R; van de Winkel, Jan G J; Wilson, Ian A; Koster, Abraham J; Taylor, Ronald P; Saphire, Erica Ollmann; Burton, Dennis R; Schuurman, Janine; Gros, Piet; Parren, Paul W H I

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden

CD20单克隆抗体的体内作用机制取决于局部肿瘤负荷。

Boross, Peter; Jansen, J H Marco; de Haij, Simone; Beurskens, Frank J; van der Poel, Cees E; Bevaart, Lisette; Nederend, Maaike; Golay, Josée; van de Winkel, Jan G J; Parren, Paul W H I; Leusen, Jeanette H W