日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource

在英国国家健康研究所炎症性肠病生物资源库中,一项基于基因型优先反向表型分析的队列研究:预防硫嘌呤类药物诱导的骨髓抑制的NUDT15基因预处理药物遗传学检测的临床应用价值和成本效益分析

Roberts, Christopher; Peters, Jaime; Sazonvos, Aleksejs; Goodman, Neil; Sharip, Mohmmed; Smith, Rebecca; Bishara, Maria; Bewshea, Claire; Lin, Simeng; Chanchlani, Neil; Hodges, Phoebe; Badrulhisham, Fakhirah; Saifuddin, Aamir; Carlson, Sean; Centritto, Andrea; Marley, Alexandra; Saad, Muhammad; Sethi-Aora, Karishma; White, Laura; Abdelmeguid, Alaa; Pele, Laetitia; Sebastian, Shaji; Selinger, Christian; Irving, Peter; Fachal, Laura; Walker, Gareth; Palmer, Rachel; Kennedy, Nick; Houghton, Jayne; Doona, Mary; Lamb, Christopher; Hyde, Chris; Parkes, Miles; Goodhand, James; Ahmad, Tariq

Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients

血液中免疫基因模块的基线表达与克罗恩病患者对TNF抑制剂治疗的初始反应相关

Bai, Benjamin Y H; Reppell, Mark; Smaoui, Nizar; Waring, Jeffrey F; Pivorunas, Valerie; Guay, Heath; Lin, Simeng; Chanchlani, Neil; Bewshea, Claire; Goodhand, James R; Kennedy, Nicholas A; Ahmad, Tariq; Anderson, Carl A

Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn's Disease

克罗恩病患者全血DNA甲基化改变与抗TNF药物浓度相关

Lin, Simeng; Hannon, Eilis; Reppell, Mark; Waring, Jeffrey F; Smaoui, Nizar; Pivorunas, Valerie; Guay, Heath; Chanchlani, Neil; Bewshea, Claire; Bai, Benjamin Y H; Kennedy, Nicholas A; Goodhand, James R; Mill, Jonathan; Ahmad, Tariq

Antibody Responses to Influenza Vaccination are Diminished in Patients With Inflammatory Bowel Disease on Infliximab or Tofacitinib

接受英夫利昔单抗或托法替尼治疗的炎症性肠病患者对流感疫苗的抗体反应减弱

Zhigang Liu, James L Alexander, Kai Yee Eng, Hajir Ibraheim, Sulak Anandabaskaran, Aamir Saifuddin, Laura Constable, Rocio Castro Seoane, Claire Bewshea, Rachel Nice, Andrea D'Mello, Gareth R Jones, Sharmili Balarajah, Francesca Fiorentino, Shaji Sebastian, Peter M Irving, Lucy C Hicks, Horace R T W

Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study

在接受英夫利昔单抗和维多珠单抗治疗的炎症性肠病患者接种三剂新冠疫苗后,针对SARS-CoV-2野生型和omicron BA.1及BA.4/5变异株的中和抗体效力(CLARITY IBD):一项前瞻性多中心队列研究的分析

Liu, Zhigang; Le, Kaixing; Zhou, Xin; Alexander, James L; Lin, Simeng; Bewshea, Claire; Chanchlani, Neil; Nice, Rachel; McDonald, Timothy J; Lamb, Christopher A; Sebastian, Shaji; Kok, Klaartje; Lees, Charlie W; Hart, Ailsa L; Pollok, Richard C; Boyton, Rosemary J; Altmann, Daniel M; Pollock, Katrina M; Goodhand, James R; Kennedy, Nicholas A; Ahmad, Tariq; Powell, Nick

The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients

肠道菌群和代谢组与免疫抑制性炎症性肠病患者新冠疫苗诱导的抗体反应减弱有关。

Alexander, James L; Mullish, Benjamin H; Danckert, Nathan P; Liu, Zhigang; Olbei, Marton L; Saifuddin, Aamir; Torkizadeh, Melissa; Ibraheim, Hajir; Blanco, Jesús Miguéns; Roberts, Lauren A; Bewshea, Claire M; Nice, Rachel; Lin, Simeng; Prabhudev, Hemanth; Sands, Caroline; Horneffer-van der Sluis, Verena; Lewis, Matthew; Sebastian, Shaji; Lees, Charlie W; Teare, Julian P; Hart, Ailsa; Goodhand, James R; Kennedy, Nicholas A; Korcsmaros, Tamas; Marchesi, Julian R; Ahmad, Tariq; Powell, Nick

Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type virus in patients with inflammatory bowel disease following three doses of COVID-19 vaccine (VIP): a prospective, multicentre, cohort study

一项前瞻性、多中心队列研究:炎症性肠病患者接种三剂新冠疫苗(VIP)后针对SARS-CoV-2 Omicron BA.4/5和野生型病毒的中和抗体反应

Liu, Zhigang; Alexander, James L; Le, Kaixing; Zhou, Xin; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Lin, Kathy Weitung; McFarlane, Leon R; Constable, Laura; Seoane, Rocio Castro; Anand, Nikhil; Bewshea, Claire; Nice, Rachel; D'Mello, Andrea; Jones, Gareth R; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M; Hicks, Lucy C; Williams, Horace Rt; Kent, Alexandra J; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal V; Teare, Julian P; Altmann, Daniel M; Boyton, Rosemary J; Hart, Ailsa L; Lees, Charlie W; Goodhand, James R; Kennedy, Nicholas A; Pollock, Katrina M; Ahmad, Tariq; Powell, Nick

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease

抗TNF生物制剂增强IgG N-糖基化物在克罗恩病中的抗炎特性

Hanić, Maja; Vučković, Frano; Deriš, Helena; Bewshea, Claire; Lin, Simeng; Goodhand, James R; Ahmad, Tariq; Trbojević-Akmačić, Irena; Kennedy, Nicholas A; Lauc, Gordan

Pretreatment Vitamin D Concentrations Do Not Predict Therapeutic Outcome to Anti-TNF Therapies in Biologic-Naïve Patients With Active Luminal Crohn's Disease

治疗前维生素D浓度不能预测未接受过生物制剂治疗的活动性管腔克罗恩病患者对TNF抑制剂治疗的疗效。

Chanchlani, Neil; Lin, Simeng; Smith, Rebecca; Roberts, Christopher; Nice, Rachel; McDonald, Timothy J; Hamilton, Benjamin; Bishara, Maria; Bewshea, Claire; Kennedy, Nicholas A; Goodhand, James R; Ahmad, Tariq

COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study

新冠疫苗诱导的炎症性肠病免疫抑制患者抗体反应(VIP):一项多中心、前瞻性、病例对照研究

Alexander, James L; Kennedy, Nicholas A; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Castro Seoane, Rocio; Liu, Zhigang; Nice, Rachel; Bewshea, Claire; D'Mello, Andrea; Constable, Laura; Jones, Gareth R; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M; Hicks, Lucy C; Williams, Horace R T; Kent, Alexandra J; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal V; Teare, Julian P; Altmann, Daniel M; Boyton, Rosemary J; Goodhand, James R; Hart, Ailsa L; Lees, Charlie W; Ahmad, Tariq; Powell, Nick