日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons

Sonlicromanol 可改善 iPSC 衍生神经元中与 m.3243A>G 异质性相关的神经元网络功能障碍和转录组变化

Teun M Klein Gunnewiek ,Anouk H A Verboven ,Iris Pelgrim ,Mark Hogeweg ,Chantal Schoenmaker ,Herma Renkema ,Julien Beyrath ,Jan Smeitink ,Bert B A de Vries ,Peter-Bram A C 't Hoen ,Tamas Kozicz ,Nael Nadif Kasri

Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice

在线粒体复合物 I 缺乏症中刺激胆固醇生物合成可降低还原应激并改善小鼠的运动功能和生存率

Tom J J Schirris, Sergio Rossell, Ria de Haas, Sanne J C M Frambach, Charlotte A Hoogstraten, G Herma Renkema, Julien D Beyrath, Peter H G M Willems, Martijn A Huynen, Jan A M Smeitink, Frans G M Russel, Richard A Notebaart

Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol's metabolite KH176m

sonlicromanol 代谢物 KH176m 选择性抑制微粒体前列腺素 E 合酶-1 介导的 PGE2 生物合成的作用机制及潜在应用

X Jiang, H Renkema, B Pennings, S Pecheritsyna, J C Schoeman, T Hankemeier, J Smeitink, J Beyrath

Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth

Sonlicromanol 的活性代谢物 KH176m 使前列腺癌干细胞 mPGES-1 过度表达正常化并抑制癌症球体生长

Xiaolan Jiang, Herma Renkema, Jan Smeitink, Julien Beyrath

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

SK 通道介导的代谢逃逸至糖酵解可抑制秀丽隐杆线虫的铁死亡并增强其抗应激能力

Inge E Krabbendam, Birgit Honrath, Benjamin Dilberger, Eligio F Iannetti, Robyn S Branicky, Tammo Meyer, Bernard Evers, Frank J Dekker, Werner J H Koopman, Julien Beyrath, Daniele Bano, Martina Schmidt, Barbara M Bakker, Siegfried Hekimi, Carsten Culmsee, Gunter P Eckert, Amalia M Dolga

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

氧化开关驱动多巴胺能帕金蛋白突变患者神经元中的线粒体自噬缺陷

Schwartzentruber, Aurelie; Boschian, Camilla; Lopes, Fernanda Martins; Myszczynska, Monika A; New, Elizabeth J; Beyrath, Julien; Smeitink, Jan; Ferraiuolo, Laura; Mortiboys, Heather

The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders

KHENERGY 研究:KH176 对线粒体 m.3243A>G 谱疾病的安全性和有效性

Mirian C H Janssen, Saskia Koene, Paul de Laat, Pleun Hemelaar, Peter Pickkers, Edwin Spaans, Rypko Beukema, Julien Beyrath, Jan Groothuis, Chris Verhaak, Jan Smeitink

Mitochondrial Migraine: Disentangling the angiopathy paradigm in m.3243A>G patients

线粒体偏头痛:解析m.3243A>G患者的血管病变范式

Smeitink, Jan; Koene, Saskia; Beyrath, Julien; Saris, Christiaan; Turnbull, Douglas; Janssen, Mirian

Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD

丙酮酸和 NAD 可挽救半乳糖诱发的 Leigh 综合征患者细胞死亡

Eligio F Iannetti, Jan A M Smeitink, Peter H G M Willems, Julien Beyrath, Werner J H Koopman

KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

KH176 通过与硫氧还蛋白系统/过氧化物酶机制相互作用,保护线粒体病变细胞免受氧化还原应激诱导的细胞死亡

Julien Beyrath, Mina Pellegrini, Herma Renkema, Lisanne Houben, Svetlana Pecheritsyna, Peter van Zandvoort, Petra van den Broek, Akkiz Bekel, Pierre Eftekhari, Jan A M Smeitink