日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

针对副作用较小的 1 型大麻素受体激动剂的虚拟库对接

Tummino Tia A, Iliopoulos-Tsoutsouvas Christos, Braz Joao M, O'Brien Evan S, Stein Reed M, Craik Veronica, Tran Ngan K, Ganapathy Suthakar, Liu Fangyu, Shiimura Yuki, Tong Fei, Ho Thanh C, Radchenko Dmytro S, Moroz Yurii S, Rosado Sian Rodriguez, Bhardwaj Karnika, Benitez Jorge, Liu Yongfeng, Kandasamy Herthana, Normand Claire, Semache Meriem, Sabbagh Laurent, Glenn Isabella, Irwin John J, Kumar Kaavya Krishna, Makriyannis Alexandros, Basbaum Allan I, Shoichet Brian K

Discovery of a functionally selective serotonin receptor (5-HT(1A)R) agonist for the treatment of pain.

发现一种功能选择性血清素受体(5-HT(1A)R)激动剂用于治疗疼痛

Ullrich Annika, Schneider Johannes, Braz João M, Neu Eduard, Staffen Nico, Stanek Markus, Bláhová Jana, Hove Tamsanqa, Albert Tamara, Allikalt Anni, Löber Stefan, Bhardwaj Karnika, Rodriguez-Rosado Sian, Fink Elissa, Rasmussen Tim, Hübner Harald, Inoue Asuka, Shoichet Brian K, Basbaum Allan I, Böttcher Bettina, Weikert Dorothee, Gmeiner Peter

Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists-Inverse Agonists with Reduced Withdrawal Effects

将 1400 万个虚拟异喹啉类化合物与 μ 和 κ 阿片受体对接,揭示了具有降低戒断反应的双重拮抗剂-反向激动剂。

Vigneron, Seth F; Ohno, Shohei; Braz, Joao; Kim, Joseph Y; Kweon, Oh Sang; Webb, Chase; Billesbølle, Christian B; Srinivasan, Karthik; Bhardwaj, Karnika; Irwin, John J; Manglik, Aashish; Basbaum, Allan I; Ellman, Jonathan A; Shoichet, Brian K

Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch

电压门控钙通道α2δ辅助亚基在小鼠疼痛和瘙痒模型中的差异性作用

Braz, Joao M; Jewell, Madison; Bhardwaj, Karnika; Rodriguez-Rosado, Sian; Craik, Veronica; Basbaum, Allan I

Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

多巴胺缺乏的斑马鱼幼体出现多模态感觉过载会导致反常运动。

Bose, Krishnashish; Bhardwaj, Karnika; Guo, Su

Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects

将 1400 万个虚拟异喹啉类化合物与 μ 和 κ 阿片受体对接,揭示了具有双重拮抗剂-反向激动剂特性且戒断反应较小的化合物。

Vigneron, Seth F; Ohno, Shohei; Braz, Joao; Kim, Joseph Y; Kweon, Oh Sang; Webb, Chase; Billesbølle, Christian; Bhardwaj, Karnika; Irwin, John; Manglik, Aashish; Basbaum, Allan I; Ellman, Jonathan A; Shoichet, Brian K

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

针对副作用较小的1型大麻素受体激动剂的大型化合物库对接

Tummino, Tia A; Iliopoulos-Tsoutsouvas, Christos; Braz, Joao M; O'Brien, Evan S; Stein, Reed M; Craik, Veronica; Tran, Ngan K; Ganapathy, Suthakar; Liu, Fangyu; Shiimura, Yuki; Tong, Fei; Ho, Thanh C; Radchenko, Dmytro S; Moroz, Yurii S; Rosado, Sian Rodriguez; Bhardwaj, Karnika; Benitez, Jorge; Liu, Yongfeng; Kandasamy, Herthana; Normand, Claire; Semache, Meriem; Sabbagh, Laurent; Glenn, Isabella; Irwin, John J; Kumar, Kaavya Krishna; Makriyannis, Alexandros; Basbaum, Allan I; Shoichet, Brian K