日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown

降解组学阐明了从人类膝骨关节炎软骨到匹配滑液的蛋白水解信息流,以及分泌型蛋白酶ADAMTS5、MMP13和CMA1对关节软骨降解的贡献。

Bhutada, Sumit; Hoyle, Anna; Piuzzi, Nicolas S; Apte, Suneel S

Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease.

ADAMTS4 对软骨寡聚基质蛋白 (COMP) 的切割产生了一种与骨关节炎和其他形式的退行性关节疾病相关的新表位

de Groot Rens, Folgado Patricia Badía, Yamamoto Kazuhiro, Martin Daniel R, Koch Christopher D, Debruin Danielle, Blagg Sophie, Minns Alexander F, Bhutada Sumit, Ahnström Josefin, Larkin Jonathan, Aspberg Anders, Önnerfjord Patrik, Apte Suneel S, Santamaria Salvatore

DICED (Database of Identified Cleavage Sites Endemic to Diseases States): A Searchable Web Interface for Terminomics/Degradomics

DICED(已识别的疾病状态特有裂解位点数据库):用于术语组学/降解组学的可搜索网络界面

Joshi, Jayadev; Bhutada, Sumit; Martin, Daniel R; Guzowski, Joyce; Blankenberg, Daniel; Apte, Suneel S

ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration.

ADAMTS7 是动脉粥样硬化的一个靶点,它与同源物 ADAMTS12 协同作用,防止粘液瘤样瓣膜退化

Mead Timothy J, Bhutada Sumit, Peruzzi Niccolò, Adegboye Janet, Seifert Deborah E, Cahill Elisabeth, Drinko Jeanne, Donnellan Eoin, Guggiliam Anu, Popovic Zoran, Griffin Brian, Tran-Lundmark Karin, Apte Suneel S

Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

在特定时间窗口内,通过基因和药理学手段联合灭活紧密连接的 ADAMTS 蛋白酶,揭示了 versican 蛋白水解和 glypican-6 在心脏发育中的不同作用

Mead Timothy J, Bhutada Sumit, Foulcer Simon J, Peruzzi Niccolò, Nelson Courtney M, Seifert Deborah E, Larkin Jonathan, Tran-Lundmark Karin, Filmus Jorge, Apte Suneel S

Proteolysis: a key post-translational modification regulating proteoglycans

蛋白水解:调控蛋白聚糖的关键翻译后修饰

Mead, Timothy J; Bhutada, Sumit; Martin, Daniel R; Apte, Suneel S