Bi-Hung相关文献与解析，生知库 | 链接生命科学的每一步

Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering

通过人工智能理性设计和抗体工程，快速恢复针对最新奥密克戎变种 JN.1 的强效中和活性。

期刊:Proceedings of the National Academy of Sciences of the United States of America

Liao, Yunji; Ma, Hang; Wang, Zhenyu; Wang, Shusheng; He, Yang; Chang, Yunsong; Zong, Huifang; Tang, Haoneng; Wang, Lei; Ke, Yong; Cai, Huiyu; Li, Ping; Tang, Jian; Chen, Hua; Drelich, Aleksandra; Peng, Bi-Hung; Hsu, Jason; Tat, Vivian; Tseng, Chien-Te K; Song, Jingjing; Yuan, Yunsheng; Wu, Mingyuan; Liu, Junjun; Yue, Yali; Zhang, Xiaoju; Wang, Ziqi; Yang, Li; Li, Jing; Ni, Xiaodan; Li, Hongshi; Xiang, Yuning; Bian, Yanlin; Zhang, Baohong; Yin, Haiyang; Dimitrov, Dimiter S; Gilly, John; Han, Lei; Jiang, Hua; Xie, Yueqing; Zhu, Jianwei

发表日期：2025

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Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolate.

与历史上分离的禽流感病毒相比，德克萨斯州奶牛 H5N1 病毒具有更强的复制能力、致病性和免疫逃避能力

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-93493-5

Octaviani Cassio Pontes, Huang Pinghan, Bi-Hung Peng, Gray Gregory C, Tseng Chien-Te K

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.

口服生物利用度高的 SARS-CoV-2 主蛋白酶抑制剂表现出更高的亲和力和更低的突变敏感性

期刊:Science Translational Medicine

影响因子:14.6

doi:10.1126/scitranslmed.adi0979

Westberg Michael, Su Yichi, Zou Xinzhi, Huang Pinghan, Rustagi Arjun, Garhyan Jaishree, Patel Puja Bhavesh, Fernandez Daniel, Wu Yan, Hao Chenzhou, Lo Chieh-Wen, Karim Marwah, Ning Lin, Beck Aimee, Saenkham-Huntsinger Panatda, Tat Vivian, Drelich Aleksandra, Peng Bi-Hung, Einav Shirit, Tseng Chien-Te K, Blish Catherine, Lin Michael Z

A murine model of post-acute neurological sequelae following SARS-CoV-2 variant infection

SARS-CoV-2 变异感染后急性神经系统后遗症的小鼠模型

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2024.1384516

Ankita Singh #, Awadalkareem Adam #, Aditi, Bi-Hung Peng, Xiaoying Yu, Jing Zou, Vikram V Kulkarni, Peter Kan, Wei Jiang, Pei-Yong Shi, Parimal Samir, Irma Cisneros, Tian Wang

Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection

COVID 相关凝血病独特病理特征的表征：对 SARS-CoV-2 感染高度耐受的 AC70 hACE2 转基因小鼠的研究

期刊:PLoS Pathogens

影响因子:5.5

doi:10.1371/journal.ppat.1011777

Aleksandra K Drelich, Kempaiah Rayavara, Jason Hsu, Panatda Saenkham-Huntsinger, Barbara M Judy, Vivian Tat, Thomas G Ksiazek, Bi-Hung Peng, Chien-Te K Tseng

Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice

使用 AC70 人 ACE2 转基因小鼠表征 SARS-CoV-2 的神经侵袭和神经病理学

期刊:Frontiers in Microbiology

影响因子:4

doi:10.3389/fmicb.2024.1455462

Jason C Hsu, Panatda Saenkham-Huntsinger, Pinghan Huang, Cassio Pontes Octaviani, Aleksandra K Drelich, Bi-Hung Peng, Chien-Te K Tseng

Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model

虫媒病毒感染增加了小鼠模型中神经退行性疾病病理发展的风险

期刊:Brain Behavior Immunity Health

影响因子:3.7

doi:10.1016/j.bbih.2024.100780

Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisneros

神经

发表日期：2024

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BALB/c mice challenged with SARS-CoV-2 B.1.351 β variant cause pathophysiological and neurological changes within the lungs and brains

感染 SARS-CoV-2 B.1.351 β 变体的 BALB/c 小鼠会导致肺部和大脑出现病理生理和神经变化

期刊:Journal of General Virology

影响因子:3.6

doi:10.1099/jgv.0.002039

Panatda Saenkham-Huntsinger, Aleksandra K Drelich, Pinghan Huang, Bi-Hung Peng, Chien-Te K Tseng

A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

一种泛变异株mRNA-LNP T细胞疫苗可保护HLA转基因小鼠免于感染SARS-CoV-2 β病毒后的死亡。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2023.1135815

Carter, Brandon; Huang, Pinghan; Liu, Ge; Liang, Yuejin; Lin, Paulo J C; Peng, Bi-Hung; McKay, Lindsay G A; Dimitrakakis, Alexander; Hsu, Jason; Tat, Vivian; Saenkham-Huntsinger, Panatda; Chen, Jinjin; Kaseke, Clarety; Gaiha, Gaurav D; Xu, Qiaobing; Griffiths, Anthony; Tam, Ying K; Tseng, Chien-Te K; Gifford, David K

VSA-2-, a novel plant-derived adjuvant for SARS-CoV-2 subunit vaccine

VSA-2，一种新型植物来源的SARS-CoV-2亚单位疫苗佐剂

Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering

通过人工智能理性设计和抗体工程，快速恢复针对最新奥密克戎变种 JN.1 的强效中和活性。

Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolate.

与历史上分离的禽流感病毒相比，德克萨斯州奶牛 H5N1 病毒具有更强的复制能力、致病性和免疫逃避能力

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.

口服生物利用度高的 SARS-CoV-2 主蛋白酶抑制剂表现出更高的亲和力和更低的突变敏感性

A murine model of post-acute neurological sequelae following SARS-CoV-2 variant infection

SARS-CoV-2 变异感染后急性神经系统后遗症的小鼠模型

Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection

COVID 相关凝血病独特病理特征的表征：对 SARS-CoV-2 感染高度耐受的 AC70 hACE2 转基因小鼠的研究

Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice

使用 AC70 人 ACE2 转基因小鼠表征 SARS-CoV-2 的神经侵袭和神经病理学

Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model

虫媒病毒感染增加了小鼠模型中神经退行性疾病病理发展的风险

BALB/c mice challenged with SARS-CoV-2 B.1.351 β variant cause pathophysiological and neurological changes within the lungs and brains

感染 SARS-CoV-2 B.1.351 β 变体的 BALB/c 小鼠会导致肺部和大脑出现病理生理和神经变化

A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

一种泛变异株mRNA-LNP T细胞疫苗可保护HLA转基因小鼠免于感染SARS-CoV-2 β病毒后的死亡。