日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

利用 CRISPR 指导的整合酶,无需双链 DNA 切割即可将大序列拖放到基因组中

Matthew T N Yarnall #,Eleonora I Ioannidi #,Cian Schmitt-Ulms #,Rohan N Krajeski #,Justin Lim,Lukas Villiger,Wenyuan Zhou,Kaiyi Jiang,Sofya K Garushyants,Nathaniel Roberts,Liyang Zhang,Christopher A Vakulskas,John A Walker 2nd,Anastasia P Kadina,Adrianna E Zepeda,Kevin Holden,Hong Ma,Jun Xie,Guangping Gao,Lander Foquet,Greg Bial,Sara K Donnelly,Yoshinari Miyata,Daniel R Radiloff,Jordana M Henderson,Andrew Ujita,Omar O Abudayyeh,Jonathan S Gootenberg

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

具有人源化肝脏的小鼠揭示了肝细胞时钟在节律行为中的作用

Anne-Sophie Delbès, Mar Quiñones, Cédric Gobet, Julien Castel, Raphaël G P Denis, Jérémy Berthelet, Benjamin D Weger, Etienne Challet, Aline Charpagne, Sylviane Metairon, Julie Piccand, Marine Kraus, Bettina H Rohde, John Bial, Elizabeth M Wilson, Lise-Lotte Vedin, Mirko E Minniti, Matteo Pedrelli, 

Behavioral and cognitive performance of humanized APOEε3/ε3 liver mice in relation to plasma apolipoprotein E levels.

人源化 APOEα3/α3 肝小鼠的行为和认知表现与血浆载脂蛋白 E 水平的关系

Kessler Kat, Giannisis Andreas, Bial Greg, Foquet Lander, Nielsen Henrietta M, Raber Jacob

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

使用肝嵌合人源化小鼠识别全氟和多氟烷基物质对人类的特定不良后果途径

Dakota R Robarts, Diego Paine-Cabrera, Manasi Kotulkar, Kaitlyn K Venneman, Sumedha Gunewardena, J Christopher Corton, Christopher Lau, Lander Foquet, Greg Bial, Udayan Apte

Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice

人源化肝脏小鼠的肝脏 APOE ε4 会改变大脑的完整性

Andreas Giannisis, Kalicharan Patra, Anna K Edlund, Lur Agirrezabala Nieto, Joan Benedicto-Gras, Simon Moussaud, Andrés de la Rosa, Daniel Twohig, Tore Bengtsson, Yuan Fu, Guojun Bu, Greg Bial, Lander Foquet, Christina Hammarstedt, Stephen Strom, Kristina Kannisto, Jacob Raber, Ewa Ellis, Henrietta

Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans

利用肝脏人源化小鼠模型揭示胆固醇脂蛋白代谢和LXR激动剂在人体内的药效学特征

Minniti, Mirko E; Pedrelli, Matteo; Vedin, Lise-Lotte; Delbès, Anne-Sophie; Denis, Raphaël G P; Öörni, Katariina; Sala, Claudia; Pirazzini, Chiara; Thiagarajan, Divya; Nurmi, Harri J; Grompe, Markus; Mills, Kevin; Garagnani, Paolo; Ellis, Ewa C S; Strom, Stephen C; Luquet, Serge H; Wilson, Elizabeth M; Bial, John; Steffensen, Knut R; Parini, Paolo

Recurrent Pheochromocytoma in an Elderly Patient

老年患者复发性嗜铬细胞瘤

Susheela, Ammu Thampi; Eldib, Howide; Vinnakota, Deepthi; Bial, Andrea; Ali, Salman; Koh, Hannah; Lavery, Brian; Gorbien, Martin

Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury

严重黄热病的消耗性凝血病与肝细胞趋向性和严重肝损伤无关

Adam L Bailey, Liang-I Kang, Luiz Gonzaga Francisco de Assis Barros D'Elia Zanella, Cássia G T Silveira, Yeh-Li Ho, Lander Foquet, Greg Bial, Broc T McCune, Amaro Nunes Duarte-Neto, Archana Thomas, Hans-Peter Raué, Kathleen Byrnes, Esper G Kallas, Mark K Slifka, Michael S Diamond1

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

基于伯氏疟原虫子孢子的抗疟疾疫苗接种平台

Mendes, António M; Machado, Marta; Gonçalves-Rosa, Nataniel; Reuling, Isaie J; Foquet, Lander; Marques, Cláudia; Salman, Ahmed M; Yang, Annie S P; Moser, Kara A; Dwivedi, Ankit; Hermsen, Cornelus C; Jiménez-Díaz, Belén; Viera, Sara; Santos, Jorge M; Albuquerque, Inês; Bhatia, Sangeeta N; Bial, John; Angulo-Barturen, Iñigo; Silva, Joana C; Leroux-Roels, Geert; Janse, Chris J; Khan, Shahid M; Mota, Maria M; Sauerwein, Robert W; Prudêncio, Miguel

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

体内评估药物对恶性疟原虫肝期寄生虫的疗效

Flannery, Erika L; Foquet, Lander; Chuenchob, Vorada; Fishbaugher, Matthew; Billman, Zachary; Navarro, Mary Jane; Betz, William; Olsen, Tayla M; Lee, Joshua; Camargo, Nelly; Nguyen, Thao; Schafer, Carola; Sack, Brandon K; Wilson, Elizabeth M; Saunders, Jessica; Bial, John; Campo, Brice; Charman, Susan A; Murphy, Sean C; Phillips, Margaret A; Kappe, Stefan Hi; Mikolajczak, Sebastian A