日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets

能够重现慢性消耗性疾病自然特征并快速发生朊病毒疾病的改良转基因小鼠模型

DeFranco, Joseph P; Kim, Sehun; Atkinson, Zoe N; Crowell, Jenna; Lei, Samantha; Bian, Jifeng; Telling, Glenn C

Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains

小鼠体内不同物种PrP的调控性共表达会影响朊病毒株的复制和宿主范围特性。

DeFranco, Joseph P; Bian, Jifeng; Kim, Sehun; Atkinson, Zoe N; Crowell, Jenna; Kang, Hae-Eun; Bodrogi, Hannah O; Christiansen, Jeffrey R; Díaz-Domínguez, Carlos M; Telling, Glenn C

Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss

小胶质细胞特异性NF-κB信号通路是朊病毒诱导的胶质细胞炎症和神经元丢失的关键调节因子。

Hay, Arielle J D; Popichak, Katriana A; Mumford, Genova; Bian, Jifeng; Shirley, Payton; Wolfrath, Lauren; Eggers, Michael; Nicholson, Eric M; Tjalkens, Ronald B; Zabel, Mark D; Moreno, Julie A

The Strain Properties of Korean and North American Chronic Wasting Disease Prions Are Indistinguishable

韩国和北美慢性消耗性疾病朊病毒的毒株特性无法区分

Sohn, Hyun Joo; DeFranco, Joseph P; Park, Hoo Chang; Park, Kyung Je; Bian, Jifeng; Crowell, Jenna; Kim, Sehun; Webster, Bailey K; Kang, Hae-Eun; Telling, Glenn C

Differences between the white-tailed and mule deer chronic wasting disease agents after passage through sheep.

白尾鹿和骡鹿慢性消耗性疾病病原体在绵羊体内传播后的差异

Frese Alexis J, Cassmann Eric D, Bian Jifeng, Mandell Leisa Z, Smadi Sura, Greenlee M Heather West, Greenlee Justin J

Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland

芬兰一头驼鹿患上慢性消耗性疾病,一种新型朊病毒株被发现

Sun, Julianna L; Kim, Sehun; Crowell, Jenna; Webster, Bailey K; Raisley, Emma K; Lowe, Diana C; Bian, Jifeng; Korpenfelt, Sirkka-Liisa; Benestad, Sylvie L; Telling, Glenn C

Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer.

经典羊瘙痒症的疾病表型在通过白尾鹿进行实验性传代后发生改变

Kokemuller Robyn D, Moore S Jo, Bian Jifeng, West Greenlee M Heather, Greenlee Justin J

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

在表达麋鹿或鹿朊病毒蛋白的小鼠体内,新型挪威朊病毒株的传播过程中,会发生与已建立的北美慢性消耗性疾病(CWD)相对应的朊病毒株构象的适应性选择。

Bian, Jifeng; Kim, Sehun; Kane, Sarah J; Crowell, Jenna; Sun, Julianna L; Christiansen, Jeffrey; Saijo, Eri; Moreno, Julie A; DiLisio, James; Burnett, Emily; Pritzkow, Sandra; Gorski, Damian; Soto, Claudio; Kreeger, Terry J; Balachandran, Aru; Mitchell, Gordon; Miller, Michael W; Nonno, Romolo; Vikøren, Turid; Våge, Jørn; Madslien, Knut; Tran, Linh; Vuong, Tram Thu; Benestad, Sylvie L; Telling, Glenn C

Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination

朊病毒感染过程中糖基化不完全会暴露朊病毒蛋白表位,从而有助于朊病毒的检测和毒株鉴别。

Kang, Hae-Eun; Bian, Jifeng; Kane, Sarah J; Kim, Sehun; Selwyn, Vanessa; Crowell, Jenna; Bartz, Jason C; Telling, Glenn C

Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

鹿和麋鹿PrP蛋白226位残基的主要结构差异决定了基因靶向小鼠中不同CWD朊病毒株的选择。

Bian, Jifeng; Christiansen, Jeffrey R; Moreno, Julie A; Kane, Sarah J; Khaychuk, Vadim; Gallegos, Joseph; Kim, Sehun; Telling, Glenn C