日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

ELP1相关Sonic hedgehog髓母细胞瘤的遗传建模鉴定出MDM2为选择性治疗靶点

Shiekh Tanveer Ahmad ,Yiran Li ,Jesus Garcia-Lopez ,Brian L Gudenas ,Jennifer Hadley ,Leena Paul ,Stephanie C Wu ,Alaa Refaat ,Marija Kojic ,Melissa Batts ,Taha Soliman ,Aaron Pitre ,Frederik Arnskötter ,Frederique Zindy ,Alun Jones ,Nathaniel R Twarog ,Anand Mayasundari ,Brandon Bianski ,Christopher Tinkle ,Abbas Shirinifard ,Laura Janke ,Meifen Lu ,Sara A Lewis ,Arzu Onar-Thomas ,Stefan M Pfister ,Amar Gajjar ,Suzanne J Baker ,Martine F Roussel ,Zoran Rankovic ,Giles W Robinson ,Brent A Orr ,Brandon Wainwright ,Anang A Shelat ,Sebastian M Waszak ,Lena M Kutscher ,Hong Lin ,Paul A Northcott

ANGI-18. DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS

ANGI-18。干扰整合素信号传导会损害H3K27M弥漫性中线胶质瘤的迁移、MYC驱动的嘌呤生物合成和干性。

Angiolari, Federica; Coretti, Alessandro; Salanne, Mathieu; Bonella, Sara; Findlay, Izac; Staudt, Dilana; Duchatel, Ryan; Jackson, Evangeline; Persson, Mika; McEwen, Holly; Delevaux, Katherine; Smith, Nathan; Vitanza, Nicholas; Cain, Jason; Hansen, Mitchell; Alvaro, Frank; Jakobsen, Lene; Larsen, Martin; Savary, Clara; Waszak, Sebastian; Dun, Matthew; Ji, Sunjong; Doherty, Robert; Mota, Mateus; Natarajan, Siva Kumar; de la Nava, Daniel; Sajjakulnukit, Peter; Peterson, Erik R; Adam, Tiffany; Niculcea, Michael; Vo, Katie; Wink, Kelsey; Bavani, Subramaniam; Sridevi, Yadavilli; Nazarian, Javad; Phillips, Joanna J; Mueller, Sabine; Filbin, Mariella; Solomon, David A; Wahl, Daniel R; Lyssiotis, Costas; Qin, Tingting; Beck, Alexander; Viswanath, Pavithra; Nuechterlein, Nicholas; Waszak, Sebastian M; Venneti, Sriram; Koschmann, Carl; Schwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Muñoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppé, Jean-Philippe; Koschmann, Carl; Ahmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskötter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul; Doherty, Robert; Wink, Kelsey; Schwark, Kallen; Ji, Sunjong; Gera, Ananya; Messinger, Dana; de la Martin, Daniel Nava; Knowles, Truman; Subramaniam, Bavani; Millet, Yves; Waszak, Sebastian; Phillips, Joanna; Solomon, David; Nazarian, Javad; Mueller, Sabine; Beck, Alexander; Coppe, Jean-Phillipe; Koschmann, Carl; Cartaxo, Rodrigo T; de la Nava, Daniel; Nieblas-Bedolla, Edwin; Niculcea, Michael; Ji, Sunjong; Natarajan, Siva Kumar; Adam, Tiffany; Clausen, Madison; Miclea, Madeline; Siada, Ruby; Schwark, Kallen; Gera, Ananya; Doherty, Robert; Lyssiotis, Costas A; Favro, Noemi; Covato, Carmelo; Brunschwig, Lucas; Waszak, Sebastian M; Nuechterlein, Nicholas; Filbin, Mariella; Vo, Tuan; Dun, Matthew D; Venneti, Sriram; Hara, Toshiro; Koschmann, Carl

The Combination of PARP and Topoisomerase 1 Inhibitors Improves Radiation Therapy for Ewing Sarcoma

PARP抑制剂和拓扑异构酶1抑制剂联合应用可改善尤文氏肉瘤的放射治疗效果

Xie, Jia; Mellado-Lagarde, Marcia M; Blankenship, Kaley; Ganguly, Debolina; Twarog, Nathaniel R; Bianski, Brandon; Kieffer, Matthew; Atkinson, Stefan; Sheppard, Heather; Gartrell, Jessica; Cler, Samuel; Federico, Sara M; Stewart, Elizabeth A; Tinkle, Christopher L; Shelat, Anang A

Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma

隐性驱动基因推断揭示了髓母细胞瘤的协同脑穿透疗法

Liu, Jingjing; Yang, Xu; Zhu, Mingrui; Dong, Xinran; Zhou, Honglei; Bianski, Brandon; Jonchere, Barbara M; Lin, Wenwei; Fu, Xiang; Yang, Lei; Freeman, Burgess B; Wang, Abigail S; Jiang, Ruilin; Chen, Taosheng; Robinson, Giles W; Roussel, Martine F; Merchant, Thomas E; Gajjar, Amar; Yu, Jiyang

Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy

卡马替尼是治疗MET融合基因驱动的儿童高级别胶质瘤的有效药物,并且与放射疗法具有协同作用。

Zuckermann, Marc; He, Chen; Andrews, Jared; Bagchi, Aditi; Sloan-Henry, Roketa; Bianski, Brandon; Xie, Jia; Wang, Yingzhe; Twarog, Nathaniel; Onar-Thomas, Arzu; Ernst, Kati J; Yang, Lei; Li, Yong; Zhu, Xiaoyan; Ocasio, Jennifer K; Budd, Kaitlin M; Dalton, James; Li, Xiaoyu; Chepyala, Divyabharathi; Zhang, Junyuan; Xu, Ke; Hover, Laura; Roach, Jordan T; Chan, Kenneth Chun-Ho; Hofmann, Nina; McKinnon, Peter J; Pfister, Stefan M; Shelat, Anang A; Rankovic, Zoran; Freeman, Burgess B 3rd; Chiang, Jason; Jones, David T W; Tinkle, Christopher L; Baker, Suzanne J

TMOD-19. GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA

TMOD-19. 生殖系ELP1缺陷使小脑颗粒神经元祖细胞对SHH髓母细胞瘤敏感

Schaufelberger, Luca; Blaskovits, J Terence; Laplaza, Ruben; Jorner, Kjell; Corminboeuf, Clemence; Kilburn, Lindsay; Franson, Andrea; Cooney, Tab; Kline, Cassie; Stoller, Schuyler; Reddy, Alyssa; Banerjee, Anu; Packer, Roger; Bendel, Anne; Skrypek, Maggie; Minturn, Jane; Abdelbaki, Mohamed; Whipple, Nicholas; Chan, Priya; Crawford, John; Crotty, Erin; Waanders, Angela; Elster, Jennifer; Raabe, Eric; George, Elizabeth; Pinto, Soniya; Supakul, Nucharin; Kraya, Adam; Prados, Michael; Nazarian, Javad; Solomon, David; Long-Boyle, Janel; Molinaro, Annette; Waszak, Sebastian; Mueller, Sabine; Tanveer Ahmad, Shiekh; Garcia-Lopez, Jesus; Li, Yiran; Hadley, Jennifer; Paul, Leena; Gudenas, Brian; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Kojic, Marija; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura Janke; Lu, Meifen; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Kutscher, Lena; Waszak, Sebastian; Lin, Hong; Northcott, Paul

ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma

ATM 抑制可增强儿童高级别胶质瘤不同分子亚群的放射疗效

Jia Xie, Teneema Kuriakose, Brandon Bianski, Nathaniel Twarog, Evan Savage, Ke Xu, Xiaoyan Zhu, Chen He, Baranda Hansen, Hong Wang, Anthony High, Yuxin Li, Jerold E Rehg, Heather S Tillman, Burgess B Freeman, Zoran Rankovic, Arzu Onar-Thomas, Yiping Fan, Gang Wu, Junmin Peng, Shondra Miller, Suzanne

Model-based evaluation of image-guided fractionated whole-brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts

基于模型的影像引导分次全脑放射治疗在儿童弥漫性内生性脑桥胶质瘤异种移植中的应用评价

Husband, Hillary R; Campagne, Olivia; He, Chen; Zhu, Xiaoyan; Bianski, Brandon M; Baker, Suzanne J; Shelat, Anang A; Tinkle, Christopher L; Stewart, Clinton F

Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma

弥漫性内生性脑桥胶质瘤适形放疗期间神经系统症状的放射剂量反应

Tinkle, Christopher L; Campbell, Kristen; Han, Yuanyuan; Li, Yimei; Bianski, Brandon; Broniscer, Alberto; Khan, Raja B; Merchant, Thomas E

Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma

影像引导下颅脊髓照射治疗极高危髓母细胞瘤的临床前模型

Smith, Stephanie M C; Bianski, Brandon M; Orr, Brent A; Harknett, Gretchen; Onar-Thomas, Arzu; Gilbertson, Richard J; Merchant, Thomas E; Roussel, Martine F; Tinkle, Christopher L