The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal
α7 烟碱受体沉默激动剂 R-47 可预防和逆转小鼠紫杉醇诱发的周围神经病变,且不会产生耐受性或改变尼古丁奖励和戒断反应
期刊:Experimental Neurology
影响因子:4.6
doi:10.1016/j.expneurol.2019.113010
Wisam Toma, S Lauren Kyte, Deniz Bagdas, Asti Jackson, Julie A Meade, Faria Rahman, Zhi-Jian Chen, Egidio Del Fabbro, Lucas Cantwell, Abhijit Kulkarni, Ganesh A Thakur, Roger L Papke, John W Bigbee, David A Gewirtz, M Imad Damaj