日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

类 PI3K 信号网络调节正常生理和疾病状态下的初级纤毛分解

Sarah E Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra, Lazaros C Foukas, Mathias Cobbaut, Sandra D Castillo, Mohammad Amin Danesh, Mahreen Adil, Arkaitz Carracedo, Mariona Graupera, Neil Q McDonald, Peter J Parker, Pedro R Cutillas, Silvia Surinova, Bart Vanhaesebroec

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

调节性 T 细胞中缺乏磷脂酰肌醇 3-激酶 VPS34 会导致致命的淋巴增生性疾病,但并不影响其发育

Courreges Christina J F, Davenport Elizabeth C M, Bilanges Benoit, Rebollo-Gomez Elena, Hukelmann Jens, Schoenfelder Priya, Edgar James R, Sansom David, Scudamore Cheryl L, Roychoudhuri Rahul, Garden Oliver A, Vanhaesebroeck Bart, Okkenhaug Klaus

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

一种用于心脏保护和神经再生的PI3Kα小分子激活剂

Grace Q Gong ,Benoit Bilanges ,Ben Allsop ,Glenn R Masson ,Victoria Roberton ,Trevor Askwith ,Sally Oxenford ,Ralitsa R Madsen ,Sarah E Conduit ,Dom Bellini ,Martina Fitzek ,Matt Collier ,Osman Najam ,Zhenhe He ,Ben Wahab ,Stephen H McLaughlin ,A W Edith Chan ,Isabella Feierberg ,Andrew Madin ,Daniele Morelli ,Amandeep Bhamra ,Vanesa Vinciauskaite ,Karen E Anderson ,Silvia Surinova ,Nikos Pinotsis ,Elena Lopez-Guadamillas ,Matthew Wilcox ,Alice Hooper ,Chandni Patel ,Maria A Whitehead ,Tom D Bunney ,Len R Stephens ,Phillip T Hawkins ,Matilda Katan ,Derek M Yellon ,Sean M Davidson ,David M Smith ,James B Phillips ,Richard Angell ,Roger L Williams ,Bart Vanhaesebroeck

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

磷脂酰肌醇-3,4-二磷酸酯的局部合成驱动黏着斑的更新。

York Posor ,Charis Kampyli ,Benoit Bilanges ,Sushila Ganguli ,Philipp A Koch ,Alexander Wallroth ,Daniele Morelli ,Michalina Jenkins ,Samira Alliouachene ,Elitza Deltcheva ,Buzz Baum ,Volker Haucke ,Bart Vanhaesebroeck

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

PI3K-Akt-mTORC1通路持续激活维持m.3243 A > G线粒体DNA突变

Chih-Yao Chung ,Kritarth Singh ,Vassilios N Kotiadis ,Gabriel E Valdebenito ,Jee Hwan Ahn ,Emilie Topley ,Joycelyn Tan ,William D Andrews ,Benoit Bilanges ,Robert D S Pitceathly ,Gyorgy Szabadkai ,Mariia Yuneva ,Michael R Duchen

Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis

III 类 PI3K Vps34 通过调节甲状腺球蛋白碘化、溶酶体蛋白水解和组织稳态来控制甲状腺激素的产生

Giuseppina Grieco, Tongsong Wang, Ophélie Delcorte, Catherine Spourquet, Virginie Janssens, Aurélie Strickaert, Héloïse P Gaide Chevronnay, Xiao-Hui Liao, Benoît Bilanges, Samuel Refetoff, Bart Vanhaesebroeck, Carine Maenhaut, Pierre J Courtoy, Christophe E Pierreux

Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency

肾近端小管中 Vps34/PI3KC3 的缺失会损害顶端转运并阻断自噬通量,从而导致类似范可尼综合征和肾功能不全。

Grieco, Giuseppina; Janssens, Virginie; Gaide Chevronnay, Héloïse P; N'Kuli, Francisca; Van Der Smissen, Patrick; Wang, Tongsong; Shan, Jingdong; Vainio, Seppo; Bilanges, Benoit; Jouret, François; Vanhaesebroeck, Bart; Pierreux, Christophe E; Courtoy, Pierre J

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth

III类PI3K(Vps34)在血小板生成和血栓形成中发挥双重作用

Valet, Colin; Levade, Marie; Chicanne, Gaëtan; Bilanges, Benoit; Cabou, Cendrine; Viaud, Julien; Gratacap, Marie-Pierre; Gaits-Iacovoni, Frédérique; Vanhaesebroeck, Bart; Payrastre, Bernard; Severin, Sonia

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

Plagl1/Zac1 结合位点和靶基因的鉴定确定了其在细胞外基质基因和印迹基因网络中的调控作用

Annie Varrault, Christelle Dantec, Anne Le Digarcher, Laëtitia Chotard, Benoit Bilanges, Hugues Parrinello, Emeric Dubois, Stéphanie Rialle, Dany Severac, Tristan Bouschet, Laurent Journot

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Vps34 PI 3-激酶失活通过重编程线粒体代谢增强胰岛素敏感性

Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M Hill, Peter J Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Ra