Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency
肾近端小管中 Vps34/PI3KC3 的缺失会损害顶端转运并阻断自噬通量,从而导致类似范可尼综合征和肾功能不全。
期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-018-32389-z
Grieco, Giuseppina; Janssens, Virginie; Gaide Chevronnay, Héloïse P; N'Kuli, Francisca; Van Der Smissen, Patrick; Wang, Tongsong; Shan, Jingdong; Vainio, Seppo; Bilanges, Benoit; Jouret, François; Vanhaesebroeck, Bart; Pierreux, Christophe E; Courtoy, Pierre J