日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation

干扰 LSD1 和 WNT 可重编转录,从而协同诱导 AML 分化。

Amir Hosseini #,Abhinav Dhall #,Nemo Ikonen,Natalia Sikora,Sylvain Nguyen,Yuqi Shen,Maria Luisa Jurgensen Amaral,Alan Jiao,Felice Wallner,Philipp Sergeev,Yuhua Lim,Yuanqin Yang,Binje Vick,Kimihito Cojin Kawabata,Ari Melnick,Paresh Vyas,Bing Ren,Irmela Jeremias ,Bethan Psaila ,Caroline A Heckman,M Andrés Blanco,Yang Shi

Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation

干扰 LSD1 和 WNT 可重编转录,从而协同诱导 AML 分化。

Amir Hosseini # ,Abhinav Dhall # ,Nemo Ikonen ,Natalia Sikora ,Sylvain Nguyen ,Yuqi Shen ,Maria Luisa Jurgensen Amaral ,Alan Jiao ,Felice Wallner ,Philipp Sergeev ,Yuhua Lim ,Yuanqin Yang ,Binje Vick ,Kimihito Cojin Kawabata ,Ari Melnick ,Paresh Vyas ,Bing Ren ,Irmela Jeremias ,Bethan Psaila ,Caroline A Heckman ,M Andrés Blanco ,Yang Shi

CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia

靶向 CCR9 和 CD1a 的 CAR-T 细胞用于治疗 T 细胞急性淋巴细胞白血病

Tirado, Néstor; Fidyt, Klaudyna; Mansilla, María José; Garcia-Perez, Alba; Martínez-Moreno, Alba; Vinyoles, Meritxell; Alcain, Juan; García-Peydró, Marina; Roca-Ho, Heleia; Fernandez-Fuentes, Narcis; Guerrero-Murillo, Mercedes; Falgàs, Aïda; Velasco-Hernandez, Talia; Bueno, Clara; Panelli, Patrizio; Mulens-Arias, Vladimir; Apostolov, Apostol; Engel, Pablo; González, Europa Azucena; Vick, Binje; Jeremias, Irmela; Caye-Eude, Aurélie; Baruchel, André; Cavé, Hélène; Genescà, Eulàlia; Ribera, Jordi; Díaz-Beyá, Marina; Martínez-Sánchez, María Victoria; Fuster, José Luis; Escudero López, Adela; Minguillón, Jordi; Pérez-Martínez, Antonio; Ramírez-Orellana, Manuel; Torrebadell, Montserrat; Díaz, Víctor M; Toribio, María L; Sánchez-Martínez, Diego; Menéndez, Pablo

Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q

利用 Pyjacker 在急性髓系白血病中发现增强子劫持,揭示了 7q 缺失导致的 MNX1 激活。

Etienne Sollier #,Anna Riedel #,Umut H Toprak #,Justyna A Wierzbinska,Dieter Weichenhan,Jan Philipp Schmid,Mariam Hakobyan,Aurore Touzart,Ekaterina Jahn,Binje Vick,Fiona Brown-Burke,Katherine Kelly,Simge Kelekçi,Anastasija Pejkovska,Ashish Goyal,Marion Bähr,Kersten Breuer,Mei-Ju May Chen,Maria Llamazares-Prada,Mark Hartmann,Maximilian Schönung,Nadia Correia,Andreas Trumpp,Yomn Abdullah,Ursula Klingmüller,Sadaf S Mughal,Benedikt Brors,Frank Westermann,Elias Ulrich,Robert J Autry,Matthias Schlesner,Sebastian Vosberg,Tobias Herold,Philipp A Greif,Dietmar Pfeifer,Michael Lübbert,Thomas Fischer,Florian H Heidel,Claudia Gebhard,Wencke Walter,Torsten Haferlach,Ann-Kathrin Eisfeld,Krzysztof Mrózek,Deedra Nicolet,Lars Bullinger,Leonie Smeenk,Claudia Erpelinck-Verschueren,Roger Mulet-Lazaro,Ruud Delwel,Aurélie Ernst,Michael Scherer,Pavlo Lutsik,Irmela Jeremias,Konstanze Döhner,Hartmut Döhner,Daniel B Lipka #,Christoph Plass #

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

在PDX模型中,结合蛋白质组学和CRISPR-Cas9筛选发现ADAM10是体内白血病所必需的。

Bahrami, Ehsan; Schmid, Jan Philipp; Jurinovic, Vindi; Becker, Martin; Wirth, Anna-Katharina; Ludwig, Romina; Kreissig, Sophie; Duque Angel, Tania Vanessa; Amend, Diana; Hunt, Katharina; Öllinger, Rupert; Rad, Roland; Frenz, Joris Maximilian; Solovey, Maria; Ziemann, Frank; Mann, Matthias; Vick, Binje; Wichmann, Christian; Herold, Tobias; Jayavelu, Ashok Kumar; Jeremias, Irmela

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

单细胞转录组图谱指导开发 CAR-T 细胞用于治疗急性髓系白血病

Adrian Gottschlich #, Moritz Thomas #, Ruth Grünmeier #, Stefanie Lesch, Lisa Rohrbacher, Veronika Igl, Daria Briukhovetska, Mohamed-Reda Benmebarek, Binje Vick, Sertac Dede, Katharina Müller, Tao Xu, Dario Dhoqina, Florian Märkl, Sophie Robinson, Andrea Sendelhofert, Heiko Schulz, Öykü Umut, Vladys

Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients

单个患者肿瘤内的不良干细胞克隆可预测急性髓系白血病(AML)患者的临床结局。

Zeller, Christina; Richter, Daniel; Jurinovic, Vindi; Valtierra-Gutiérrez, Ilse A; Jayavelu, Ashok Kumar; Mann, Matthias; Bagnoli, Johannes W; Hellmann, Ines; Herold, Tobias; Enard, Wolfgang; Vick, Binje; Jeremias, Irmela

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

持续双特异性分子暴露引起的 T 细胞衰竭可通过无治疗间隔得到改善

Nora Philipp, Maryam Kazerani, Alyssa Nicholls, Binje Vick, Jan Wulf, Tobias Straub, Michaela Scheurer, Amelie Muth, Gerulf Hänel, Daniel Nixdorf, Monika Sponheimer, Malte Ohlmeyer, Sonja M Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Kai Rejeski, Oliver Weigert,

Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia

Translatome 蛋白质组学证实自噬是急性髓系白血病对靶向 FLT3 抑制剂的耐药机制

Sebastian E Koschade, Kevin Klann, Shabnam Shaid, Binje Vick, Jan A Stratmann, Marlyn Thölken, Laura M Meyer, The Duy Nguyen, Julia Campe, Laura M Moser, Susanna Hock, Fatima Baker, Christian T Meyer, Frank Wempe, Hubert Serve, Evelyn Ullrich, Irmela Jeremias, Christian Münch #, Christian H Brandts 

Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia

翻译组蛋白质组学鉴定出自噬是急性髓系白血病中对靶向FLT3抑制剂产生耐药性的机制

Sebastian E Koschade   ,Kevin Klann,Shabnam Shaid ,Binje Vick,Jan A Stratmann,Marlyn Thölken,Laura M Meyer,The Duy Nguyen,Julia Campe,Laura M Moser ,Susanna Hock,Fatima Baker ,Christian T Meyer,Frank Wempe,Hubert Serve ,Evelyn Ullrich ,Irmela Jeremias ,Christian Münch # ,Christian H Brandts #