日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies

利用可解释人工智能对转录进行建模,揭示了启动子和基因体处特定情境下的表观遗传基因调控。

Chhatbar, Kashyap; Bird, Adrian; Sanguinetti, Guido

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach.

翻译阅读框决定了 MeCP2 中 C 端移码缺失的致病性:一种替代治疗方法。

Guy Jacky, Hein Elena, Alexander-Howden Bea, von Bock Und Polach Timur, Mathieson Tricia, Kleinstiver Benjamin P, Zoghbi Huda, Bird Adrian

Loss of CpG island immunity to DNA methylation induced by mutation

突变导致CpG岛对DNA甲基化的免疫力丧失

Horsthemke, Bernhard; Bird, Adrian

CDKL5 deficiency disorder: a pathophysiology of neural maintenance

CDKL5 缺乏症:神经维持的病理生理学

Kind, Peter C; Bird, Adrian

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation

Mbd2 能够促进肠道肿瘤的发生,同时抑制促进肿瘤发生的炎症反应。

May, Stephanie; Owen, Heather; Phesse, Toby J; Greenow, Kirsty R; Jones, Gareth-Rhys; Blackwood, Adam; Cook, Peter C; Towers, Christopher; Gallimore, Awen M; Williams, Geraint T; Stürzl, Michael; Britzen-Laurent, Nathalie; Sansom, Owen J; MacDonald, Andrew S; Bird, Adrian P; Clarke, Alan R; Parry, Lee

MeCP2 mutations: progress towards understanding and treating Rett syndrome

MeCP2 基因突变:在理解和治疗雷特综合征方面取得的进展

Shah, Ruth R; Bird, Adrian P

MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain.

MeCP2 识别胞嘧啶甲基化的三核苷酸和二核苷酸序列,从而调节哺乳动物大脑中的转录

Lagger Sabine, Connelly John C, Schweikert Gabriele, Webb Shaun, Selfridge Jim, Ramsahoye Bernard H, Yu Miao, He Chuan, Sanguinetti Guido, Sowers Lawrence C, Walkinshaw Malcolm D, Bird Adrian

Rett Syndrome: Crossing the Threshold to Clinical Translation

雷特综合征:跨越门槛,迈向临床转化

Katz, David M; Bird, Adrian; Coenraads, Monica; Gray, Steven J; Menon, Debashish U; Philpot, Benjamin D; Tarquinio, Daniel C

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System

表观遗传机制在神经系统基因表达调控中的作用

Cholewa-Waclaw, Justyna; Bird, Adrian; von Schimmelmann, Melanie; Schaefer, Anne; Yu, Huimei; Song, Hongjun; Madabhushi, Ram; Tsai, Li-Huei

Sequence-specific DNA binding by AT-hook motifs in MeCP2

MeCP2 中 AT-hook 基序的序列特异性 DNA 结合

Lyst, Matthew J; Connelly, John; Merusi, Cara; Bird, Adrian