日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices.

BCL-2 化学耐药突变体的结构见解及其被 BAD BH3 螺旋钉合物靶向的作用。

DeAngelo Thomas M, Adhikary Utsarga, Korshavn Kyle J, Seo Hyuk-Soo, Brotzen-Smith Clara R, Camara Christina M, Dhe-Paganon Sirano, Bird Gregory H, Wales Thomas E, Walensky Loren D

A triple-action PROTAC for wild-type p53 cancer therapy

用于野生型p53癌症治疗的三重作用PROTAC

Bird, Gregory H; Adhikary, Utsarga; Schmidt, Michael J; Godes, Marina; Tesar, Bethany; Camara, Christina M; Paulo, Joao A; Vidlak, Julia F; DeAngelo, Thomas M; Marquez, Marilyn; Gokhale, Prafulla; Li, Ruitong; Ho Sui, Shannan J; Cameron, Michael D; Gygi, Steven P; Walensky, Loren D

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype.

利用共价肽靶向NEDD9-SH3可控制内皮细胞表型

Samokhin Andriy O, Seo Hyuk-Soo, Leed Alison, Hajian Behnoush, Bird Gregory H, McKinney David C, Saha Progyaparamita, Daum Jacqueline, Moroco Jamie A, Yehl Jenna, Kornfilt David, Szczeniowski Anna, Petrunak Elyse, Horner Steven, Kalin Jay H, Leymarie Nancy, Kaushik Virendar K, Walensky Loren D, Cole Philip A, Oldham William M, Steinhauser Matthew L, Dhe-Paganon Sirano, Maron Bradley A

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency

人类VLCAD缺乏症中突变酶膜靶向缺陷的结构基础

Prew, Michelle S; Camara, Christina M; Botzanowski, Thomas; Moroco, Jamie A; Bloch, Noah B; Levy, Hannah R; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Bird, Gregory H; Herce, Henry D; Gygi, Micah A; Escudero, Silvia; Wales, Thomas E; Engen, John R; Walensky, Loren D

Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation"

通过“丝氨酸连接”生成高效稳定的GLP-1类似物

Levine, Paul M; Craven, Timothy W; Li, Xinting; Balana, Aaron T; Bird, Gregory H; Godes, Marina; Salveson, Patrick J; Erickson, Patrick W; Lamb, Mila; Ahlrichs, Maggie; Murphy, Michael; Ogohara, Cassandra; Said, Meerit Y; Walensky, Loren D; Pratt, Matthew R; Baker, David

Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.

通过二硫键连接鉴定抗凋亡蛋白BFL-1的共价分子抑制剂

Harvey Edward P, Hauseman Zachary J, Cohen Daniel T, Rettenmaier T Justin, Lee Susan, Huhn Annissa J, Wales Thomas E, Seo Hyuk-Soo, Luccarelli James, Newman Catherine E, Guerra Rachel M, Bird Gregory H, Dhe-Paganon Sirano, Engen John R, Wells James A, Walensky Loren D

Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor

胰高血糖素样肽-1受体的烃链肽激动剂

Bird, Gregory H; Fu, Accalia; Escudero, Silvia; Godes, Marina; Opoku-Nsiah, Kwadwo; Wales, Thomas E; Cameron, Michael D; Engen, John R; Danial, Nika N; Walensky, Loren D

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

迭代优化法制备出靶向 Mcl-1 的交联肽,该肽对 Mcl-1 依赖性癌细胞具有选择性细胞毒性。

Rezaei Araghi, Raheleh; Bird, Gregory H; Ryan, Jeremy A; Jenson, Justin M; Godes, Marina; Pritz, Jonathan R; Grant, Robert A; Letai, Anthony; Walensky, Loren D; Keating, Amy E

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

碳氢化合物交联肽螺旋的细胞摄取生物物理决定因素

Bird, Gregory H; Mazzola, Emanuele; Opoku-Nsiah, Kwadwo; Lammert, Margaret A; Godes, Marina; Neuberg, Donna S; Walensky, Loren D

Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides

利用烃链交联肽靶向碱性螺旋-环-螺旋转录因子的挑战

Edwards, Amanda L; Meijer, Dimphna H; Guerra, Rachel M; Molenaar, Remco J; Alberta, John A; Bernal, Federico; Bird, Gregory H; Stiles, Charles D; Walensky, Loren D