日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic.

一种可系统递送的脂质偶联 siRNA，靶向 DUX4，作为面肩肱型肌营养不良症的治疗方法

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2025.101513
Daman Katelyn, Yan Jing, Biscans Annabelle, Echeverria Dimas, Shmushkovich Taisia, Wolfson Alexey, Alterman Julia F, Khvorova Anastasia, Emerson Charles P Jr
其它
发表日期：2025
文献求助 收藏

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

用于微流控尺度非侵入式原位表征的片上光子检测技术

期刊:Sensors
影响因子:3.5
doi:10.3390/s24051529
Kurdadze, Tamar; Lamadie, Fabrice; Nehme, Karen A; Teychené, Sébastien; Biscans, Béatrice; Rodriguez-Ruiz, Isaac
发表日期：2024
文献求助 收藏

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

合理设计JAK1选择性siRNA抑制剂以调节皮肤自身免疫

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-023-42714-4
Qi Tang ，Hassan H Fakih ，Mohammad Zain Ui Abideen ，Samuel R Hildebrand ，Khashayar Afshari ，Katherine Y Gross ，Jacquelyn Sousa ，Allison S Maebius ，Christina Bartholdy ，Pia Pernille Søgaard ，Malene Jackerott ，Vignesh Hariharan ，Ashley Summers ，Xueli Fan ，Ken Okamura ，Kathryn R Monopoli ，David A Cooper ，Dimas Echeverria ，Brianna Bramato ，Nicholas McHugh ，Raymond C Furgal ，Karen Dresser ，Sarah J Winter ，Annabelle Biscans ，Jane Chuprin ，Nazgol-Sadat Haddadi ，Shany Sherman ，Ümmügülsüm Yıldız-Altay ，Mehdi Rashighi ，Jillian M Richmond ，Claire Bouix-Peter ，Carine Blanchard ，Adam Clauss ，Julia F Alterman ，Anastasia Khvorova ，John E Harris
JAK/STAT
免疫/内分泌
JAK1
发表日期：2023
文献求助 收藏

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors

单次玻璃体内注射四价 siRNA 可在小鼠和猪的光感受器中表现出强大而有效的基因沉默

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2023.102088
Shun-Yun Cheng, Jillian Caiazzi, Annabelle Biscans, Julia F Alterman, Dimas Echeverria, Nicholas McHugh, Matthew Hassler, Samson Jolly, Delaney Giguere, Joris Cipi, Anastasia Khvorova, Claudio Punzo
信号转导
Mouse
发表日期：2023
文献求助 收藏

Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

治疗性寡核苷酸：改善内体运输的化学策略展望

期刊:Cells
影响因子:5.2
doi:10.3390/cells12182253
Mangla, Priyanka; Vicentini, Quentin; Biscans, Annabelle
发表日期：2023
文献求助 收藏

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

二价 siRNA 在肺中具有生物利用度，可有效阻断 SARS-CoV-2 感染

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2219523120
Vignesh N Hariharan, Minwook Shin, Ching-Wen Chang, Daniel O'Reilly, Annabelle Biscans, Ken Yamada, Zhiru Guo, Mohan Somasundaran, Qi Tang, Kathryn Monopoli, Pranathi Meda Krishnamurthy, Gitali Devi, Nicholas McHugh, David A Cooper, Dimas Echeverria, John Cruz, Io Long Chan, Ping Liu, Sun-Young Lim,
代谢
免疫
心血管
新冠
发表日期：2023
文献求助 收藏

RNAi-based modulation of IFN-γ signaling in skin

基于RNAi的皮肤IFN-γ信号通路调控

期刊:Molecular Therapy
影响因子:12.1
doi:10.1016/j.ymthe.2022.04.019
Qi Tang ，Jacquelyn Sousa ，Dimas Echeverria ，Xueli Fan ，Ying-Chao Hsueh ，Khashayar Afshari ，Nicholas MeHugh ，David A Cooper ，Lorenc Vangjeli ，Kathryn Monopoli ，Ken Okamura ，Annabelle Biscans ，Adam Clauss ，John E Harris ，Anastasia Khvorova
IFN-γ
信号转导
发表日期：2022
文献求助 收藏

Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo

工程化可电离脂质 siRNA 结合物可增强内体逃逸，但会在体内引起毒性

期刊:Journal of Controlled Release
影响因子:10.5
doi:10.1016/j.jconrel.2022.07.041
Annabelle Biscans, Socheata Ly, Nicholas McHugh, David A Cooper, Anastasia Khvorova
毒理研究
发表日期：2022
文献求助 收藏

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

siRNA 的化学优化，以安全有效地沉默胎盘 sFLT1

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2022.06.009
Sarah M Davis, Vignesh N Hariharan, Agnes Lo, Anton A Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F Alterman, S Ananth Karumanchi, Melissa J Moore, Anastasia Khvorova
发表日期：2022
文献求助 收藏

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

PK 修饰锚定物可显著改变 siRNA 治疗的清除动力学、组织分布和疗效

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2022.06.005
Bruno M D C Godinho, Emily G Knox, Samuel Hildebrand, James W Gilbert, Dimas Echeverria, Zachary Kennedy, Reka A Haraszti, Chantal M Ferguson, Andrew H Coles, Annabelle Biscans, Jillian Caiazzi, Julia F Alterman, Matthew R Hassler, Anastasia Khvorova
信号转导
发表日期：2022
文献求助 收藏