日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic.

一种可系统递送的脂质偶联 siRNA，靶向 DUX4，作为面肩肱型肌营养不良症的治疗方法

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2025.101513
Daman Katelyn, Yan Jing, Biscans Annabelle, Echeverria Dimas, Shmushkovich Taisia, Wolfson Alexey, Alterman Julia F, Khvorova Anastasia, Emerson Charles P Jr
其它
发表日期：2025
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Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

治疗性寡核苷酸：改善内体运输的化学策略展望

期刊:Cells
影响因子:5.2
doi:10.3390/cells12182253
Mangla, Priyanka; Vicentini, Quentin; Biscans, Annabelle
发表日期：2023
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Innovative developments and emerging technologies in RNA therapeutics

RNA疗法领域的创新发展和新兴技术

期刊:RNA Biology
影响因子:3.4
doi:10.1080/15476286.2022.2027150
Halloy, François; Biscans, Annabelle; Bujold, Katherine E; Debacker, Alexandre; Hill, Alyssa C; Lacroix, Aurélie; Luige, Olivia; Strömberg, Roger; Sundstrom, Linda; Vogel, Jörg; Ghidini, Alice
发表日期：2022
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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles.

将二十二碳酸与 siRNA 结合，可实现功能性且安全的递送至骨骼肌和心肌

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2020.12.023
Biscans Annabelle, Caiazzi Jillian, McHugh Nicholas, Hariharan Vignesh, Muhuri Manish, Khvorova Anastasia
心血管
发表日期：2021
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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.

疏水修饰的siRNA的化学结构和硫代磷酸酯含量会影响肝外分布和疗效

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaa595
Biscans Annabelle, Caiazzi Jillian, Davis Sarah, McHugh Nicholas, Sousa Jacquelyn, Khvorova Anastasia
表观遗传
发表日期：2020
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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.

用于体内功能性肝外siRNA递送的多种脂质缀合物

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gky1239
Biscans Annabelle, Coles Andrew, Haraszti Reka, Echeverria Dimas, Hassler Matthew, Osborn Maire, Khvorova Anastasia
发表日期：2019
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The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.

脂肪酸缀合物的价态会影响 siRNA 在体内的药代动力学、分布和疗效

期刊:Journal of Controlled Release
影响因子:11.5
doi:10.1016/j.jconrel.2019.03.028
Biscans Annabelle, Coles Andrew, Echeverria Dimas, Khvorova Anastasia
代谢
发表日期：2019
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Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth

探索早期地球上RNA核苷和核苷酸的出现

期刊:Life-Basel
影响因子:3.4
doi:10.3390/life8040057
Biscans, Annabelle
发表日期：2018
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Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

合成和评价代谢稳定的 O-磷酸胆碱-N-二十二碳六烯酰-L-丝氨酸 siRNA 缀合物在小鼠脑中的实质保留和功效

期刊:Bioconjugate Chemistry
影响因子:3.9
doi:10.1021/acs.bioconjchem.7b00226
Nikan Mehran, Osborn Maire F, Coles Andrew H, Biscans Annabelle, Godinho Bruno M D C, Haraszti Reka A, Sapp Ellen, Echeverria Dimas, DiFiglia Marian, Aronin Neil, Khvorova Anastasia
代谢
Mouse
发表日期：2017
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