日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells

阿尔茨海默病相关的PLCG2变异体可改变人诱导多能干细胞来源的小胶质细胞样细胞的状态和功能。

Logan M Bedford ,Kaylee D Tutrow ,Karly Hooper ,Evan J Messenger ,Melody Hernandez ,Bruce T Lamb ,Jason S Meyer ,Timothy I Richardson ,Stephanie J Bissel

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes

载脂蛋白ε4通过减少活跃髓鞘化的少突胶质细胞,加剧Aβ淀粉样变性小鼠模型中的白质损伤。

Al-Amin, Md Mamun; Kim, Byungwook; Karahan, Hande; Tate, Mason D; Walsh, Sam P; Puntambekar, Shweta S; Bissel, Stephanie J; Lamb, Bruce T; Wang, Nian; Kim, Jungsu

PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.

PLCG2 调节 TREM2 的表达和信号传导以应对阿尔茨海默病病理

Messenger Evan J, Baar Sydney A, Bedford Logan M, Tsai Andy P, Lin Peter Bor-Chian, Ferguson Chloe A, Xu Guixiang, Wallace Abigail, Landreth Gary E, Lamb Bruce T, Bissel Stephanie J

Driving sustainable change: A systematic map of behaviorally informed interventions to promote sustainable mobility behavior

推动可持续变革:一套系统化的行为干预措施方案,旨在促进可持续出行行为

Bissel, Michael; Gossen, Maike; Reisch, Lucia A; Sunstein, Cass R

Caspase-11 Mediated Hyperinflammation Impairs CD8(+) T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

Caspase-11介导的过度炎症反应会损害重症SARS-CoV-2感染中的CD8(+) T细胞免疫和病毒清除能力

Eltobgy, Mostafa M; Shamseldin, Mohamed M; Whitham, Owen; Amer, Heba M; Atkinson, Jeffery; Badr, Asmaa; Hall, Jesse; Omran, Jihad; Gupta, Gauruv; Hassan, Yara; Abdelaleem, Rabab; Perez, Richard; Faber, Sarah; Pietrzak, Maciej; Webb, Amy; Zhang, Xiaoli; Kenney, Adam D; Bissel, Destiny; Estfanous, Shady; Daily, Kylene; Mcnamara, Andrew; Kc, Mahesh; Peeples, Mark E; Hemann, Emily A; Nimjee, Shahid M; Cormet-Boyaka, Estelle; Li, Jianrong; Boyaka, Prosper N; Yount, Jacob S; Segal, Benjamin; Dubey, Purnima; Amer, Amal O

Identification of PLCγ2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCγ2激活剂

Hawksley, J C; Clayton, Brent; Massey, Steven M; Chu, Shaoyou; Mason, Emily R; Bissel, Stephanie J; Bedford, Logan M; Rizzo, Stacey J Sukoff; Mesecar, Andrew D; Kaiser, Bridget L; Lendy, Emma K; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function.

具有 CX3CR1-V249I 基因变异的人类诱导多能干细胞衍生的小胶质细胞表现出功能障碍表型,并调节神经元的生长和功能。

Tutrow Kaylee D, Harkin Jade, Varghese Laurna, Hernandez Melody, Huang Kang-Chieh, Fang Yue, Wilcox Parker, Bedford Logan, Lin Tsai-Yu, Zhang Chi, Gomes Cátia, Puntambekar Shweta, Bissel Stephanie, Lamb Bruce T, Meyer Jason S

Trem2-deficiency aggravates and accelerates age-related myelin degeneration

Trem2 缺陷会加剧并加速与年龄相关的髓鞘退化。

Tyler J McCray ,Logan M Bedford ,Stephanie J Bissel # ,Bruce T Lamb #

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease

磷脂酶C-γ2的基因变异会改变小胶质细胞的表型和功能,并导致阿尔茨海默病风险的差异。

Andy P Tsai ,Chuanpeng Dong ,Peter Bor-Chian Lin ,Adrian L Oblak ,Gonzalo Viana Di Prisco ,Nian Wang ,Nicole Hajicek ,Adam J Carr ,Emma K Lendy ,Oliver Hahn ,Micaiah Atkins ,Aulden G Foltz ,Jheel Patel ,Guixiang Xu ,Miguel Moutinho ,John Sondek ,Qisheng Zhang ,Andrew D Mesecar ,Yunlong Liu ,Brady K Atwood ,Tony Wyss-Coray ,Kwangsik Nho ,Stephanie J Bissel ,Bruce T Lamb ,Gary E Landreth

Network analysis identifies strain-dependent response to tau and tau seeding-associated genes

网络分析确定了对 tau 和 tau 播种相关基因的菌株依赖性反应

Dominic J Acri, Yanwen You, Mason D Tate, Hande Karahan, Pablo Martinez, Brianne McCord, A Daniel Sharify, Sutha John, Byungwook Kim, Luke C Dabin, Stéphanie Philtjens, H R Sagara Wijeratne, Tyler J McCray, Daniel C Smith, Stephanie J Bissel, Bruce T Lamb, Cristian A Lasagna-Reeves, Jungsu Kim