日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

全基因组 CRISPR 筛选鉴定出 GRA38 是弓形虫适应富含脂质环境过程中脂质稳态的关键调控因子

Bitew, Mebratu A; Paredes-Santos, Tatiana C; Maru, Parag; Krishnamurthy, Shruthi; Wang, Yifan; Sangaré, Lamba O; Duley, Samuel; Yamaryo-Botté, Yoshiki; Botté, Cyrille Y; Saeij, Jeroen P J

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions.

全基因组 CRISPR 筛选发现 GRA38 是弓形虫适应富含脂质的环境过程中脂质稳态的关键调节因子

Bitew Mebratu A, Paredes-Santos Tatiana C, Maru Parag, Krishnamurthy Shruthi, Wang Yifan, Sangaré Lamba O, Duley Samuel, Yamaryo-Botté Yoshiki, Botte Cyrille, Saeij Jeroen P J

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells.

CRISPR筛选鉴定出弓形虫基因,这些基因决定了寄生虫在γ干扰素刺激的人类细胞中的适应性

Krishnamurthy Shruthi, Maru Parag, Wang Yifan, Bitew Mebratu A, Mukhopadhyay Debanjan, Yamaryo-Botté Yoshiki, Paredes-Santos Tatiana C, Sangaré Lamba O, Swale Christopher, Botté Cyrille Y, Saeij Jeroen P J

De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever

从头合成NAD对于伯氏考克斯体(Coxiella burnetii,被忽视的人畜共患病Q热的病原体)的细胞内复制至关重要。

Bitew, Mebratu A; Khoo, Chen Ai; Neha, Nitika; De Souza, David P; Tull, Dedreia; Wawegama, Nadeeka K; Newton, Hayley J; Sansom, Fiona M