日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease

β-肾上腺素能受体拮抗剂具有促炎作用,并会加剧阿尔茨海默病小鼠模型中的神经炎症。

Andrew K Evans ,Pooneh M Ardestani ,Bitna Yi ,Heui Hye Park ,Rachel K Lam ,Mehrdad Shamloo

Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist

利用偏向性和选择性β-1肾上腺素能受体部分激动剂调节5XFAD阿尔茨海默病小鼠模型中的神经炎症和病理

Pooneh Memar Ardestani ,Andrew K Evans ,Bitna Yi ,Tiffany Nguyen ,Laurence Coutellier ,Mehrdad Shamloo

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

发现新型可渗透大脑且 G 蛋白偏向的 β-1 肾上腺素受体部分激动剂,用于治疗神经认知障碍

Bitna Yi, Alam Jahangir, Andrew K Evans, Denise Briggs, Kristine Ravina, Jacqueline Ernest, Amir B Farimani, Wenchao Sun, Jayakumar Rajadas, Michael Green, Evan N Feinberg, Vijay S Pande, Mehrdad Shamloo

Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis

内质网应激在 PS19 和 APPSwe 小鼠 Tau 蛋白病和淀粉样变性模型中的学习和记忆障碍以及阿尔茨海默病样神经病理学中的作用

Denise Isabelle Briggs, Erwin Defensor, Pooneh Memar Ardestani, Bitna Yi, Michelle Halpain, Guy Seabrook, Mehrdad Shamloo

Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies

发现苯甲酰胺类似物作为人类神经元烟碱受体的负变构调节剂:药效团建模和构效关系研究

Bitna Yi, Sihui Long, Tatiana F González-Cestari, Brandon J Henderson, Ryan E Pavlovicz, Karl Werbovetz, Chenglong Li, Dennis B McKay

Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors

确定人类 α4β2 神经元烟碱受体选择性负变构调节剂的假定抑制位点

Brandon J Henderson, Tatiana F González-Cestari, Bitna Yi, Ryan E Pavlovicz, R Thomas Boyd, Chenglong Li, Stephen C Bergmeier, Dennis B McKay

Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors

磺酰基哌嗪类似物作为人类神经元烟碱受体新型负变构调节剂的构效关系研究

Brandon J Henderson, Daniel J Carper, Tatiana F González-Cestari, Bitna Yi, Kiran Mahasenan, Ryan E Pavlovicz, Martin L Dalefield, Robert S Coleman, Chenglong Li, Dennis B McKay