Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcγ receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity
使用靶向人Fcγ受体I型的无佐剂疫苗进行黏膜免疫,可有效预防肺炎链球菌PspA感染,其机制是通过补体和乳铁蛋白介导的杀菌活性。
期刊:Infection and Immunity
影响因子:2.8
doi:10.1128/IAI.05511-11
Bitsaktsis, Constantine; Iglesias, Bibiana V; Li, Ying; Colino, Jesus; Snapper, Clifford M; Hollingshead, Susan K; Pham, Giang; Gosselin, Diane R; Gosselin, Edmund J