日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita.

小鼠中 Ten1 的缺失会导致端粒缩短,并模拟人类先天性角化不良症

Sanz-Moreno Adrián, Becker Lore, Xie Kan, da Silva-Buttkus Patricia, Dragano Nathalia R V, Aguilar-Pimentel Antonio, Amarie Oana V, Calzada-Wack Julia, Kraiger Markus, Leuchtenberger Stefanie, Seisenberger Claudia, Marschall Susan, Rathkolb Birgit, Scifo Enzo, Liu Ting, Thanabalasingam Anoja, Sanchez-Vazquez Raul, Martinez Paula, Blasco Maria A, Savage Sharon A, Fuchs Helmut, Ehninger Dan, Gailus-Durner Valérie, de Angelis Martin Hrabê

The multiomics blueprint of the individual with the most extreme lifespan

寿命最长个体的多组学蓝图

Santos-Pujol, Eloy; Noguera-Castells, Aleix; Casado-Pelaez, Marta; García-Prieto, Carlos A; Vasallo, Claudia; Campillo-Marcos, Ignacio; Quero-Dotor, Carlos; Crespo-García, Eva; Bueno-Costa, Alberto; Setién, Fernando; Ferrer, Gerardo; Davalos, Veronica; Mereu, Elisabetta; Pluvinet, Raquel; Arribas, Carles; Torre, Carolina de la; Villavicencio, Francisco; Sumoy, Lauro; Granada, Isabel; Coles, Natalie S; Acha, Pamela; Solé, Francesc; Mallo, Mar; Mata, Caterina; Peregrina, Sara; Gabaldón, Toni; Llirós, Marc; Pujolassos, Meritxell; Carreras-Torres, Robert; Lluansí, Aleix; García-Gil, Librado Jesús; Aldeguer, Xavier; Samino, Sara; Torné, Pol; Ribalta, Josep; Guardiola, Montse; Amigó, Núria; Yanes, Oscar; Martínez, Paula; Sánchez-Vázquez, Raúl; Blasco, Maria A; Oviedo, Jose; Lemos, Bernardo; Rius-Bonet, Julia; Torrubiano, Marta; Massip-Salcedo, Marta; Khidir, Kamal A; Cao, Thong Huy; Quinn, Paulene A; Jones, Donald J L; Macip, Salvador; Brigos-Barril, Eva; Moldes, Mauricio; Barteri, Fabio; Muntané, Gerard; Laayouni, Hafid; Navarro, Arcadi; Esteller, Manel

Telomere Dysfunction in Renal Tubular Epithelial Cells Leads to Kidney Fibrosis

肾小管上皮细胞端粒功能障碍导致肾纤维化

Saraswati, Sarita; Martínez, Paula; Serrano, Rosa; Mejías, Diego; Graña-Castro, Osvaldo; Díaz, Ruth Álvarez; Flores, Juana María; Blasco, Maria A

Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations.

携带与肺纤维化相关的人类同源shelterin POT1-L259S突变的小鼠表现出端粒酶缺乏样表型,随着小鼠世代的增加,端粒会缩短。

Sánchez-Vázquez Raúl, Burgaz García-Oteyza Sonia, Serrano Rosa, Flores Juana M, Martínez Paula, Blasco Maria A

Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles

TRF1端粒结合蛋白的缺失会导致小鼠体型变瘦,代谢谱发生改变。

Ruano, Jessica Louzame; Bejarano, Leire; Serrano, Rosa; Diaz, Ruth Alvarez; Flores, Juana Maria; López, Ana Cayuela; Blasco, Maria A

Author Correction: Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres

作者更正:肾成纤维细胞参与了与端粒功能障碍相关的肾纤维化中的纤维化改变。

Saraswati, Sarita; Martínez, Paula; Serrano, Rosa; Mejías, Diego; Graña-Castro, Osvaldo; Álvarez Díaz, Ruth; Blasco, Maria A

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

MARK-AGE 研究发现,衰老会影响欧洲大型人群血液细胞中端粒下 DNA 甲基化。

Bacalini, Maria Giulia; Reale, Anna; Malavolta, Marco; Ciccarone, Fabio; Moreno-Villanueva, María; Dollé, Martijn E T; Jansen, Eugène; Grune, Tilman; Gonos, Efstathios S; Schön, Christiane; Bernhardt, Jürgen; Grubeck-Loebenstein, Beatrix; Sikora, Ewa; Toussaint, Olivier; Debacq-Chainiaux, Florence; Capri, Miriam; Hervonen, Antti; Hurme, Mikko; Slagboom, P Eline; Breusing, Nicolle; Aversano, Valentina; Tagliatesta, Stefano; Franceschi, Claudio; Blasco, Maria A; Bürkle, Alexander; Caiafa, Paola; Zampieri, Michele

AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer

在致癌性K-Ras诱导的肺癌背景下,AAV9介导的端粒酶激活不会加速肿瘤发生。

Muñoz-Lorente, Miguel A; Martínez, Paula; Tejera, Águeda; Whittemore, Kurt; Moisés-Silva, Ana Carolina; Bosch, Fàtima; Blasco, Maria A

Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span

利用TRF1端粒基因进行基因治疗可以挽救衰老过程中降低的TRF1水平,并延长小鼠的健康寿命。

Derevyanko, Aksinya; Whittemore, Kurt; Schneider, Ralph P; Jiménez, Verónica; Bosch, Fàtima; Blasco, Maria A

Telomere-driven diseases and telomere-targeting therapies

端粒驱动疾病和端粒靶向疗法

Martínez, Paula; Blasco, Maria A