日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo.

四价抗体在体内比促红细胞生成素更有效、更强效的促红细胞生成剂。

Adams Jarrett J, Blazer Levi L, Chung Jacky, Karimi Minoo, Davidson Taylor, Blair Bailey, Waddle Carlos, Hokanson Craig A, Bruce Heather A, Singer Alexander U, Tombak Eva-Maria, Gildemann Kiira, Tamberg Nele, Kiiver Kaja, Ustav Mart Jr, Ma Yue, Colombo Luigi, Huang Lily Jun-Shen, Michnick Stephen W, Moe Orson W, Sidhu Sachdev S

Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.

靶向 EphA2 的合成抗体可诱导具有不同激活方式的多种信号传导活性簇

Adams Jarrett J, Bruce Heather A, Subramania Suryasree, Ploder Lynda, Garcia Julia, Pot Isabelle, Blazer Levi L, Singer Alexander U, Sidhu Sachdev S

An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo.

不对称四抗体是体外和体内促红细胞生成素受体的强效激动剂

Adams Jarrett J, Blazer Levi L, Chung Jacky, Karimi Minoo, Davidson Taylor, Bruce Heather A, Singer Alexander U, Yang Ning, Cardarelli Lia, Pot Isabelle, Colombo Luigi, Huang Lily Jun-Shen, Ma Yue, Michnick Stephen W, Moe Orson W, Sidhu Sachdev S

Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones

具有改进的晶格堆积和增强的肘部构象灵活性的抗原结合片段作为结晶伴侣

Bruce, Heather A; Singer, Alexander U; Blazer, Levi L; Luu, Khanh; Ploder, Lynda; Pavlenco, Alevtina; Kurinov, Igor; Adams, Jarrett J; Sidhu, Sachdev S

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties

一种经过基因工程改造、具有更广泛特异性的合成抗Frizzled抗体表现出增强的抗肿瘤特性

Pavlovic, Zvezdan; Adams, Jarrett J; Blazer, Levi L; Gakhal, Amandeep K; Jarvik, Nick; Steinhart, Zachary; Robitaille, Mélanie; Mascall, Keith; Pan, James; Angers, Stephane; Moffat, Jason; Sidhu, Sachdev S

Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986

CCG-4986 对 G 蛋白信号调节因子-Gα 蛋白-蛋白相互作用的变构抑制

Roman, David L; Blazer, Levi L; Monroy, C Aaron; Neubig, Richard R

Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins

可逆的、变构的小分子G蛋白信号调节蛋白抑制剂

Blazer, Levi L; Roman, David L; Chung, Alfred; Larsen, Martha J; Greedy, Benjamin M; Husbands, Stephen M; Neubig, Richard R

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

在以单珠单化合物为核心的筛选中,鉴定出一种RGS4共价肽抑制剂。

Roof, Rebecca A; Roman, David L; Clements, Samuel T; Sobczyk-Kojiro, Katarzyna; Blazer, Levi L; Ota, Shodai; Mosberg, Henry I; Neubig, Richard R

Novel peptide ligands of RGS4 from a focused one-bead, one-compound library

从聚焦的单珠单化合物库中筛选出RGS4的新型肽配体

Roof, Rebecca A; Sobczyk-Kojiro, Katarzyna; Turbiak, Anjanette J; Roman, David L; Pogozheva, Irina D; Blazer, Levi L; Neubig, Richard R; Mosberg, Henry I