日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The unique role of nucS-mediated noncanonical mismatch repair in Mycobacterium tuberculosis resistance evolution

nucS介导的非经典错配修复在结核分枝杆菌耐药性进化中的独特作用

期刊:mBio
影响因子:4.7
doi:10.1128/mbio.03310-25
Martín-Blecua, Isabel; Sastre-Domínguez, Jorge; Valverde, José Ramón; García-Bravo, Pablo; Ruiz-Enamorado, Ángel; Prados-Rosales, Rafael; Das, Lahari; Jacobs, William R Jr; San Millán, Álvaro; Blázquez, Jesús; Gullón, Sonia
发表日期：2026
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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

MYC激活会损害细胞内在的IFNγ信号传导，并导致肺癌对PD-1/PD-L1抑制剂产生耐药性。

期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2023.101006
Juan J Alburquerque-Bejar ,Pablo Navajas-Chocarro ,Maria Saigi ,Ana Ferrero-Andres ,Juan M Morillas ,Andrea Vilarrubi ,Antonio Gomez ,José L Mate ,Ana M Munoz-Marmol ,Octavio A Romero ,Pedro Blecua ,Veronica Davalos ,Manel Esteller ,Eva Pros ,Paula Llabata ,Manuel Torres-Diz ,Anna Esteve-Codina ,Montse Sanchez-Cespedes
PD-L1
IFNγ
MYC
细胞生物学
肺癌
信号转导
肿瘤
肿瘤免疫
PD-1
发表日期：2023
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G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy

蛋白偶联受体 183 介导伯基特淋巴瘤通过抗 CD20/PI3Kδi 双重疗法对 CD47 免疫检查点阻断的敏感性

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2023.1130052
Marcelo Lima Ribeiro, Núria Profitós-Pelejà, Juliana Carvalho Santos, Pedro Blecua, Diana Reyes-Garau, Marc Armengol, Miranda Fernández-Serrano, Hari P Miskin, Francesc Bosch, Manel Esteller, Emmanuel Normant, Gael Roué
信号转导
免疫
肿瘤
淋巴瘤
FCM
IF
IHC-P
WB
Checkpoint
PI3K/Akt
Human
GP183
发表日期：2023
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Refinement of computational identification of somatic copy number alterations using DNA methylation microarrays illustrated in cancers of unknown primary

利用DNA甲基化微阵列改进体细胞拷贝数变异的计算识别方法，以原发灶不明的癌症为例进行说明

期刊:Briefings in Bioinformatics
影响因子:7.7
doi:10.1093/bib/bbac161
Blecua, Pedro; Davalos, Veronica; de Villasante, Izar; Merkel, Angelika; Musulen, Eva; Coll-SanMartin, Laia; Esteller, Manel
肿瘤
表观遗传
肿瘤免疫
DNA甲基化
细胞生物学
发表日期：2022
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Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus

非经典错配修复蛋白NucS调控脓肿分枝杆菌抗生素耐药性的产生

期刊:Microbiology Spectrum
影响因子:3.8
doi:10.1128/spectrum.02228-22
Fressatti Cardoso, Rosilene; Martín-Blecua, Isabel; Pietrowski Baldin, Vanessa; Meneguello, Jean Eduardo; Valverde, José Ramón; Blázquez, Jesús; Castañeda-García, Alfredo
信号转导
发表日期：2022
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Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non-Hodgkin Lymphoma

新型BTK抑制剂TG-1701的抗肿瘤活性与B细胞非霍奇金淋巴瘤患者中Ikaros信号通路的破坏有关

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-21-1067
Ribeiro, Marcelo Lima; Reyes-Garau, Diana; Vinyoles, Meritxell; Profitós Pelejà, Núria; Santos, Juliana Carvalho; Armengol, Marc; Fernández-Serrano, Miranda; Sedó Mor, Alícia; Bech-Serra, Joan J; Blecua, Pedro; Musulen, Eva; De La Torre, Carolina; Miskin, Hari; Esteller, Manel; Bosch, Francesc; Menéndez, Pablo; Normant, Emmanuel; Roué, Gaël
B细胞
肿瘤
Ikaros
肿瘤免疫
信号转导
淋巴瘤
BTK
细胞生物学
免疫/内分泌
发表日期：2021
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Specificity and mutagenesis bias of the mycobacterial alternative mismatch repair analyzed by mutation accumulation studies

通过突变积累研究分析分枝杆菌替代错配修复的特异性和诱变偏差

期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.aay4453
A Castañeda-García, I Martín-Blecua, E Cebrián-Sastre, A Chiner-Oms, M Torres-Puente, I Comas, J Blázquez
免疫
发表日期：2020
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The DNA methylation landscape of hematological malignancies: an update

血液系统恶性肿瘤的DNA甲基化图谱：最新进展

期刊:Molecular Oncology
影响因子:4.5
doi:10.1002/1878-0261.12744
Blecua, Pedro; Martinez-Verbo, Laura; Esteller, Manel
肿瘤
表观遗传
肿瘤免疫
DNA甲基化
发表日期：2020
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Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response

错配修复缺陷肿瘤的遗传多样性会影响抗PD-1免疫疗法的反应。

期刊:Science
影响因子:45.8
doi:10.1126/science.aau0447
Mandal, Rajarsi; Samstein, Robert M; Lee, Ken-Wing; Havel, Jonathan J; Wang, Hao; Krishna, Chirag; Sabio, Erich Y; Makarov, Vladimir; Kuo, Fengshen; Blecua, Pedro; Ramaswamy, Apoorva T; Durham, Jennifer N; Bartlett, Bjarne; Ma, Xiaoxiao; Srivastava, Raghvendra; Middha, Sumit; Zehir, Ahmet; Hechtman, Jaclyn F; Morris, Luc Gt; Weinhold, Nils; Riaz, Nadeem; Le, Dung T; Diaz, Luis A Jr; Chan, Timothy A
肿瘤
肿瘤免疫
PD-1
免疫/内分泌
发表日期：2019
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High subclonal fraction of 17p deletion is associated with poor prognosis in multiple myeloma

17p缺失的高亚克隆比例与多发性骨髓瘤预后不良相关

期刊:Blood
影响因子:23.1
doi:10.1182/blood-2018-10-880831
Thakurta, Anjan; Ortiz, Maria; Blecua, Pedro; Towfic, Fadi; Corre, Jill; Serbina, Natalya V; Flynt, Erin; Yu, Zhinuan; Yang, Zhihong; Palumbo, Antonio; Dimopoulos, Meletios A; Gutierrez, Norma C; Goldschmidt, Hartmut; Sonneveld, Pieter; Avet-Loiseau, Herve
骨髓瘤
多发性骨髓瘤
发表日期：2019
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