日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

鉴定 3-磷酸甘油酸脱氢酶小分子抑制剂以靶向癌症中的丝氨酸生物合成

Edouard Mullarky, Natasha C Lucki, Reza Beheshti Zavareh, Justin L Anglin, Ana P Gomes, Brandon N Nicolay, Jenny C Y Wong, Stefan Christen, Hidenori Takahashi, Pradeep K Singh, John Blenis, J David Warren, Sarah-Maria Fendt, John M Asara, Gina M DeNicola, Costas A Lyssiotis, Luke L Lairson, Lewis C

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

mTOR抑制剂可减少Pten+/-小鼠的肿瘤形成并使p70/S6激酶活性恢复正常。

Podsypanina, K; Lee, R T; Politis, C; Hennessy, I; Crane, A; Puc, J; Neshat, M; Wang, H; Yang, L; Gibbons, J; Frost, P; Dreisbach, V; Blenis, J; Gaciong, Z; Fisher, P; Sawyers, C; Hedrick-Ellenson, L; Parsons, R

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

驱动蛋白的货物被鉴定为JIP支架蛋白和相关信号分子

Verhey, K J; Meyer, D; Deehan, R; Blenis, J; Schnapp, B J; Rapoport, T A; Margolis, B

Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1.

对与 p90 核糖体 S6 激酶 1 的膜靶向相关的调控事件进行表征

Richards S A, Dreisbach V C, Murphy L O, Blenis J

p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation

在凝血酶诱导的血小板活化和聚集过程中,p42丝裂原活化蛋白激酶和p90核糖体S6激酶被选择性磷酸化和激活。

Papkoff, J; Chen, R H; Blenis, J; Forsman, J

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity

生长因子诱导的激酶在调节血清反应因子DNA结合活性的位点对其进行磷酸化。

Rivera, V M; Miranti, C K; Misra, R P; Ginty, D D; Chen, R H; Blenis, J; Greenberg, M E

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

ERK和RSK编码蛋白激酶的核定位和调控

Chen, R H; Sarnecki, C; Blenis, J

Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro

pp90rsk 的协同调控以及一种独特的蛋白丝氨酸/苏氨酸激酶活性,该活性可在体外磷酸化重组 pp90rsk

Chung, J; Chen, R H; Blenis, J

Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction

生长因子、佛波酯和环磷酸腺苷介导的信号转导对Swiss 3T3细胞中pp90rsk磷酸化和S6磷酸转移酶活性的调控

Chen, R H; Chung, J; Blenis, J

Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation

非洲爪蟾S6蛋白激酶同源物(pp90rsk)在体细胞中的鉴定:细胞增殖起始过程中的磷酸化和激活

Chen, R H; Blenis, J