日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

导致 CMT2N 的氨酰化结构域突变体能够使 Nrp1 与 AlaRS 相互作用。

Sun, Litao; Wei, Na; Kuhle, Bernhard; Blocquel, David; Novick, Scott; Matuszek, Zaneta; Zhou, Huihao; He, Weiwei; Zhang, Jingjing; Weber, Thomas; Horvath, Rita; Latour, Philippe; Pan, Tao; Schimmel, Paul; Griffin, Patrick R; Yang, Xiang-Lei

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells

CMT疾病的严重程度与患者细胞中组氨酰tRNA合成酶的突变诱导开放构象相关,而非氨酰化丧失相关。

Blocquel, David; Sun, Litao; Matuszek, Zaneta; Li, Sheng; Weber, Thomas; Kuhle, Bernhard; Kooi, Grace; Wei, Na; Baets, Jonathan; Pan, Tao; Schimmel, Paul; Yang, Xiang-Lei

Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy

另一种稳定的构象可能导致蛋白质错误相互作用,从而将tRNA合成酶与周围神经病变联系起来。

Blocquel, David; Li, Sheng; Wei, Na; Daub, Herwin; Sajish, Mathew; Erfurth, Maria-Luise; Kooi, Grace; Zhou, Jiadong; Bai, Ge; Schimmel, Paul; Jordanova, Albena; Yang, Xiang-Lei

Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy.

鞘氨醇-1-磷酸裂解酶缺乏症会导致夏科-马里-图斯神经病

Atkinson Derek, Nikodinovic Glumac Jelena, Asselbergh Bob, Ermanoska Biljana, Blocquel David, Steiner Regula, Estrada-Cuzcano Alejandro, Peeters Kristien, Ooms Tinne, De Vriendt Els, Yang Xiang-Lei, Hornemann Thorsten, Milic Rasic Vedrana, Jordanova Albena

Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS

两个晶体结构揭示了人丙氨酰tRNA合成酶(AlaRS)C-Ala结构域的改造设计。

Sun, Litao; Song, Youngzee; Blocquel, David; Yang, Xiang-Lei; Schimmel, Paul

Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus

亨德拉病毒核蛋白与磷蛋白相互作用的原子分辨率描述

Communie, Guillaume; Habchi, Johnny; Yabukarski, Filip; Blocquel, David; Schneider, Robert; Tarbouriech, Nicolas; Papageorgiou, Nicolas; Ruigrok, Rob W H; Jamin, Marc; Jensen, Malene Ringkjøbing; Longhi, Sonia; Blackledge, Martin

Interaction between the C-terminal domains of measles virus nucleoprotein and phosphoprotein: a tight complex implying one binding site

麻疹病毒核蛋白和磷蛋白C端结构域之间的相互作用:形成紧密复合物,提示存在一个结合位点

Blocquel, David; Habchi, Johnny; Costanzo, Stéphanie; Doizy, Anthony; Oglesbee, Michael; Longhi, Sonia