日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies.

用于中枢神经系统小胶质细胞替代策略的 CSF1R 抑制剂耐药模型。

Chadarevian Jean Paul, Nguyen Jasmine, Le Lauren, Ayala L Angel, Chadarevian Alina L, Zhou Cuiwen, Escobar Adrian, Do Abby T, Deynega Ekaterina, Mansour Kimiya, Hasselmann Jonathan, Eskandari-Sedighi Ghazaleh, Lombroso Sonia I, Bennett F Chris, Inlay Matthew A, Davtyan Hayk, Blurton-Jones Mathew

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk

髓系细胞中 LACTB 表达降低与琥珀酰肉碱水平升高和阿尔茨海默病风险降低相关。

Romero-Molina, Carmen; Gomez-Gutierrez, Ruben; See, Wen Yi; Patel, Tulsi; Davtyan, Hayk; Ma, Jiacheng; Xu, Quanyun; Sewell, Michael; Allton, Kendra; McReynolds, Morgan; Calderon, Olivia; Lightfoot, Yaima L; Bommer, Guido; Cruchaga, Carlos; Blurton-Jones, Mathew; Ray, William J; Marcora, Edoardo; Goate, Alison M

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

DNA损伤会导致神经元出现一种独特的、与阿尔茨海默病相关的衰老状态。

Hughes, Jun-Wei B; Sandholm, Anja; Croll, Duncan; Senchyna, Fiona; Schneider, Kevin; Butterfield, Rachel; McHugh, Tyne L M; Brown, Ian; Deguchi, Hideto; Hilsabeck, Tyler A U; Mak, Sally; Wilson, Kenneth A; Davtyan, Hayk; Blurton-Jones, Mathew; Herdy, Joseph; Higuchi-Sanabria, Ryo; Gage, Fred H; Furman, David; Ellerby, Lisa M; Desprez, Pierre-Yves; Campisi, Judith

Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.

免疫检查点TIM-3调节小胶质细胞和阿尔茨海默病

Kimura Kimitoshi, Subramanian Ayshwarya, Yin Zhuoran, Khalilnezhad Ahad, Wu Yufan, He Danyang, Dixon Karen O, Chitta Udbhav Kasyap, Ding Xiaokai, Adhikari Niraj, Guzchenko Isabell, Zhang Xiaoming, Tang Ruihan, Pertel Thomas, Myers Samuel A, Aastha Aastha, Nomura Masashi, Eskandari-Sedighi Ghazaleh, Singh Vasundhara, Liu Lei, Lambden Conner, Kleemann Kilian L, Gupta Neha, Barry Jen-Li, Durao Ana, Cheng Yiran, Silveira Sebastian, Zhang Huiyuan, Suhail Aamir, Delorey Toni, Rozenblatt-Rosen Orit, Freeman Gordon J, Selkoe Dennis J, Weiner Howard L, Blurton-Jones Mathew, Cruchaga Carlos, Regev Aviv, Suvà Mario L, Butovsky Oleg, Kuchroo Vijay K

Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy

吸入氙气可调节小胶质细胞,并改善淀粉样变性和tau蛋白病小鼠模型中的疾病症状。

Brandao, Wesley; Jain, Nimansha; Yin, Zhuoran; Kleemann, Kilian L; Carpenter, Madison; Bao, Xin; Serrano, Javier R; Tycksen, Eric; Durao, Ana; Barry, Jen-Li; Baufeld, Caroline; Guneykaya, Dilansu; Zhang, Xiaoming; Litvinchuk, Alexandra; Jiang, Hong; Rosenzweig, Neta; Pitts, Kristen M; Aronchik, Michael; Yahya, Taha; Cao, Tian; Takahashi, Marcelo Kenzo; Krishnan, Rajesh; Davtyan, Hayk; Ulrich, Jason D; Blurton-Jones, Mathew; Ilin, Ilya; Weiner, Howard L; Holtzman, David M; Butovsky, Oleg

Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support.

人类 iPSC 衍生的 APOE4/4 阿尔茨海默病星形胶质细胞表现出衰老和促炎状态,从而损害神经元支持。

Caceres-Palomo Laura, Sanchez-Mejias Elisabeth, Trujillo-Estrada Laura, Perez-Moreno Juan Jose, Lopez-Oliva Elba, Lim Tau En, DeFlitch Leah, Chang Serena H, Kampman Lucas, Corces M Ryan, Blurton-Jones Mathew, Moreno-Gonzalez Ines, Pascual Alberto, Vitorica Javier, Garcia-Leon Juan Antonio, Gutierrez Antonia

Excitatory neuronal PLCG2 correlates with tau pathology in Alzheimer's disease via the alteration of the autophagy‐lysosomal pathway

兴奋性神经元PLCG2通过改变自噬-溶酶体途径与阿尔茨海默病中的tau蛋白病理相关。

Zhou, Hongzhong; Zhu, Liwen; Zhang, Yajun; Chen, Lichan; Gou, Dong-Mei; Zhang, Haohua; Hua, Rongmao; Song, Jianning; Qiu, Chuanghua; Yao, Fu-Wen; Wei, Xiafei; Gu, Dayong; Xu, Yong; Kim, Tae Yeon; Acosta, Diana M; Sweeney, Nicholas; Bonte, Marie‐Amandine; Guo, Qi; Rose, Ethan; Chadarevian, Jean Paul; Ma, Qin; Davtyan, Hayk; Blurton‐Jones, Mathew; Fu, Hongjun

Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release

淀粉样前体蛋白和C99是人小胶质细胞Hv1通道的亚基,它们能增强电流和炎症介质的释放。

Zhao, Ruiming; Sophanpanichkul, Punyanuch; Chadarevian, Jean Paul; Ding, Yiwen; Dai, Hui; Nayak, Maha; Davtyan, Hayk; Blurton-Jones, Mathew; Goldstein, Steve A N

Retraction Note: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

撤稿声明:基于MultiTEP的靶向人α-突触核蛋白的DNA疫苗的有效性和免疫原性:IND申报研究的前奏

Kim, Changyoun; Hovakimyan, Armine; Zagorski, Karen; Antonyan, Tatevik; Petrushina, Irina; Davtyan, Hayk; Chailyan, Gor; Hasselmann, Jonathan; Iba, Michiyo; Adame, Anthony; Rockenstein, Edward; Szabo, Marcell; Blurton-Jones, Mathew; Cribbs, David H; Ghochikyan, Anahit; Masliah, Eliezer; Agadjanyan, Michael G

Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease

晚发性阿尔茨海默病小鼠模型中的脑血管改变

Crouzet, Christian; Xie, Danny F; Laquindanum Nuqui, Maiella Nona; Hasselman, Jonathan; Phan, Thinh; Wilson, Robert H; Baglietto-Vargas, David; Da Cunha, Celia; Davtyan, Hayk; Forner, Stefania; Jullienne, Amandine; Bazrafkan, Afsheen; LaFerla, Frank M; Obenaus, Andre; Blurton-Jones, Mathew; Akbari, Yama; Green, Kim N; Choi, Bernard