日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.

将 CBL TKBD 锁定在其天然构象中,为突变型 CBL 依赖性白血病提供了一种新的治疗机会

Ahmed Syed Feroj, Anand Jayanthi, Zhang Wei, Buetow Lori, Rishi Loveena, Mitchell Louise, Bohlen Jonathan, Lilla Sergio, Sibbet Gary J, Nixon Colin, Patel Amrita, Majorek Karolina A, Zanivan Sara, Bustamante Jacinta C, Sidhu Sachdev S, Blyth Karen, Huang Danny T

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis.

p53 和 TIGAR 促进氧化还原控制,以防止与代谢功能障碍相关的脂肪性肝炎

Wittke Celine I, Cheung Eric C, Athineos Dimitris, Clements Nicola, Butler Liam, Hughes Mark, Morrison Vivienne, Watt Dale M, Blyth Karen, Vousden Karen H, Humpton Timothy J

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells.

组蛋白伴侣 HIRA 的失活揭示了黑素细胞正常胚胎发育与成体黑素干细胞维持之间的联系

Jaber-Hijazi Farah, Arnold Rouven, Swaminathan Karthic, Gilroy Kathryn, Wenzel Alexander T, Lagnado Anthony, Kirschner Kristina, Robertson Neil, Reid Claire, Fullarton Neil, Pawlikowski Jeff, Rai Taranjit Singh, Baranyk Ian, Shi Christina Huan, Yip Kevin Y, Blyth Karen, Mesirov Jill P, Harris Melissa L, Passos João F, Machesky Laura M, Adams Peter D

AKT/mTOR as a targetable hub to overcome multimodal resistance to EGFR inhibitors in oesophageal squamous cell carcinoma

AKT/mTOR作为可靶向的枢纽,有望克服食管鳞状细胞癌对EGFR抑制剂的多模式耐药性

Spender, Lindsay C; Watt, Dale M; Baxter, Mark A; Shuttleworth, Morven K; Walker, Kateah; Savage, Alice R; Clements, Hollie A; Kapelyukh, Yury; Bray, Susan E; King, Sharon I; Wolf, C Roland; Inman, Gareth J; Walsh, Shaun V; Blyth, Karen; Petty, Russell D

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos.

ARID1A 的缺失通过与 AP1 亚基 cFos 的协同作用,加速前列腺肿瘤的发生,并使其呈现增殖性胶原蛋白缺乏的表型

Hartley Andrew, Galbraith Laura C A, Shaw Robin, Tibbo Amy, Veeratterapillay Rajan, Wilson Laura, Heer Rakesh, Blyth Karen, Leung Hing, Ahmad Imran

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments.

微转移的代谢适应改变了细胞外囊泡的产生,从而产生了侵袭性微环境

Gounis Michalis, Campos America V, Shokry Engy, Mitchell Louise, Deshmukh Ruhi, Dornier Emmanuel, Rooney Nicholas, Dhayade Sandeep, Pardo Luis, Moore Madeleine, Novo David, Mowat Jenna, Jamieson Craig, Kay Emily, Zanivan Sara, Paul Nikki R, Mitchell Claire, Nixon Colin, Macpherson Iain, Tardito Saverio, Sumpton David, Blyth Karen, Norman Jim C, Clarke Cassie J

A precision image-guided model of stereotactic ablative radiotherapy for hepatocellular carcinoma.

肝细胞癌立体定向消融放射治疗的精确图像引导模型

May Stephanie, Stevenson Katrina, Alqarafi Bashaer, Yin Swe Kyi Lai, Bloom Algernon, Mackintosh Agata, Müller Miryam, Georgakopoulou Anastasia, Drake Thomas M, Kiourtis Christos, Karim Saadia A, Nixon Colin, Cadden Barbara, Duffton Aileen, Grose Derek, Lewis David Y, Blyth Karen, Chalmers Anthony J, Bird Thomas G

Correction to: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

更正:Brf1缺失而非过表达会破坏肠道、肝脏和胰腺的组织稳态。

Liko, Dritan; Mitchell, Louise; Campbell, Kirsteen J; Ridgway, Rachel A; Jones, Carolyn; Dudek, Kate; King, Ayala; Bryson, Sheila; Stevenson, David; Blyth, Karen; Strathdee, Douglas; Morton, Jennifer P; Bird, Thomas G; Knight, John R P; Willis, Anne E; Sansom, Owen J

Better translation via collaboration: The MRC National Mouse Genetics Network

通过合作实现更佳翻译:MRC国家小鼠遗传学网络

Sansom, Owen; Wells, Sara; Kent, David; Wood, Andrew; Pitceathly, Robert D S; Isles, Anthony; Liu, Karen; Twigg, Stephen; Blyth, Karen; Chesler, Louis

Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment

TIGAR 调节 ROS 信号在肿瘤微环境中诱导癌症调节反应

Eric C Cheung, Douglas Strathdee, David Stevenson, Jack Coomes, Karen Blyth, Karen H Vousden