Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody
三羟基黄酮（Tricin）通过抑制PDGF-BB诱导的SRC/MAPK/AP-1/PD-L1信号通路，选择性地对抗KRAS突变型非小细胞肺癌，并增强抗PD-1抗体的抗肿瘤作用。
期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1594213
Li, Jia-Xin; Tan, Shi-Yu; Li, Li-Qi; Zheng, Yu-Hong; Zhao, Lin; Zhu, Hui-Rong; He, Hai-Lang; Zhang, Yan-Yu; Li, Run-Ze; Bao, Tian-Yu; Zhang, Yi-Zhong; Yang, Xiao-Man; Zhang, Hao; Chen, Hui-Hui; Wu, Bo-Wen; Lin, Xin; Lin, Xiao-Sheng; Lin, Yin Cheng; Sui, Xin-Bing; Xie, Ying; Zhou, Xian-Mei; Yan, Pei-Yu
肺癌
肿瘤
肿瘤免疫
PDGF-BB
信号转导
SRC
MAPK/ERK
PD-L1
细胞生物学
RAS
PD-1
