Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways
Sigma-1 受体激活可通过 PERK 和 IP3R-VDAC1-MCU 信号通路缓解内质网应激和线粒体钙超载，从而减弱 DOX 诱导的心脏毒性
期刊:Biology Direct
影响因子:5.7
doi:10.1186/s13062-025-00617-y
Zixuan Li #, Qian Ran #, Chuan Qu #, Shan Hu, Shengyu Cui, You Zhou, Bo Shen, Bo Yang0
