日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection

表型异质性决定了B细胞对通过疫苗接种和感染反复暴露于SARS-CoV-2的反应。

Lela Kardava ,James Lim ,Clarisa M Buckner ,Felipe Lopes de Assis ,Xiaozhen Zhang ,Wei Wang ,Mattie L Melnyk ,Omar El Merhebi ,Krittin Trihemasava ,I-Ting Teng ,Robin Carroll ,Yogita Jethmalani ,Mike Castro ,Bob C Lin ,Lauren H Praiss ,Catherine A Seamon ,Peter D Kwong ,Richard A Koup ,Leonid Serebryannyy ,David C Nickle ,Tae-Wook Chun ,Susan Moir

Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates

黏膜腺病毒疫苗加强免疫可诱导产生 IgA,并持久预防非人灵长类动物的 XBB.1.16 感染。

Matthew Gagne ,Barbara J Flynn ,Shayne F Andrew ,Josue Marquez ,Dillon R Flebbe ,Anna Mychalowych ,Evan Lamb ,Meredith E Davis-Gardner ,Matthew R Burnett ,Leonid A Serebryannyy ,Bob C Lin ,Zohar E Ziff ,Erin Maule ,Robin Carroll ,Mursal Naisan ,Yogita Jethmalani ,Laurent Pessaint ,John-Paul M Todd ,Nicole A Doria-Rose ,James Brett Case ,Igor P Dmitriev ,Elena A Kashentseva ,Baoling Ying ,Alan Dodson ,Katelyn Kouneski ,Sijy O'Dell ,Bushra Wali ,Madison Ellis ,Sucheta Godbole ,Farida Laboune ,Amy R Henry ,I-Ting Teng ,Danyi Wang ,Lingshu Wang ,Qiong Zhou ,Serge Zouantchangadou ,Alex Van Ry ,Mark G Lewis ,Hanne Andersen ,Peter D Kwong ,David T Curiel ,Mario Roederer ,Martha C Nason ,Kathryn E Foulds ,Mehul S Suthar ,Michael S Diamond ,Daniel C Douek ,Robert A Seder

Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains

多价 DNA 初免蛋白加强疫苗诱导的人类 CD4 结合位点抗体可中和跨进化枝的 2 级 HIV 毒株

Shixia Wang, Kun-Wei Chan, Danlan Wei, Xiuwen Ma, Shuying Liu, Guangnan Hu, Saeyoung Park, Ruimin Pan, Ying Gu, Alexandra F Nazzari, Adam S Olia, Kai Xu, Bob C Lin, Mark K Louder, Krisha McKee, Nicole A Doria-Rose, David Montefiori, Michael S Seaman, Tongqing Zhou, Peter D Kwong, James Arthos, Xiang

Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

抗体定向进化揭示了 HIV-1 融合肽位点增强中和的机制

Bailey B Banach, Sergei Pletnev, Adam S Olia, Kai Xu, Baoshan Zhang, Reda Rawi, Tatsiana Bylund, Nicole A Doria-Rose, Thuy Duong Nguyen, Ahmed S Fahad, Myungjin Lee, Bob C Lin, Tracy Liu, Mark K Louder, Bharat Madan, Krisha McKee, Sijy O'Dell, Mallika Sastry, Arne Schön, Natalie Bui, Chen-Hsiang She

Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

通过减少可变域上的净正电荷来改善 HIV 中和 VRC01 类抗体的药代动力学

Young D Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C Lin, Tracy Liu, Mark K Louder, Reda Rawi, Mateo Reveiz, Andrew J Schaub, Chen-Hsiang Shen, Nicole A Doria-Rose, Paolo Lusso, John R Mascola, Peter D Kwong

Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains

多价 DNA 初免蛋白加强疫苗诱导的人类 CD4 结合位点抗体可中和跨进化枝 Tier-2-HIV 毒株

Shixia Wang, Kun-Wei Chan, Danlan Wei, Xiuwen Ma, Shuying Liu, Guangnan Hu, Saeyoung Park, Ruimin Pan, Ying Gu, Alexandra F Nazzari, Adam S Olia, Kai Xu, Bob C Lin, Mark K Louder, Nicole A Doria-Rose, David Montefiori, Michael S Seaman, Tongqing Zhou, Peter D Kwong, James Arthos, Xiang-Peng Kong, Sh

Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial

AAV8 为 HIV 感染者提供广谱中和抗体的安全性和耐受性:第 1 阶段剂量递增试验

Joseph P Casazza, Evan M Cale, Sandeep Narpala, Galina V Yamshchikov, Emily E Coates, Cynthia S Hendel, Laura Novik, LaSonji A Holman, Alicia T Widge, Preeti Apte, Ingelise Gordon, Martin R Gaudinski, Michelle Conan-Cibotti, Bob C Lin, Martha C Nason, Olga Trofymenko, Shinyi Telscher, Sarah H Plumme

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

在已接种疫苗的猕猴中,mRNA-1273 或 mRNA-Omicron 加强免疫可诱导类似的 B 细胞扩增、中和反应以及对 Omicron 的保护作用。

Matthew Gagne ,Juan I Moliva ,Kathryn E Foulds ,Shayne F Andrew ,Barbara J Flynn ,Anne P Werner ,Danielle A Wagner ,I-Ting Teng ,Bob C Lin ,Christopher Moore ,Nazaire Jean-Baptiste ,Robin Carroll ,Stephanie L Foster ,Mit Patel ,Madison Ellis ,Venkata-Viswanadh Edara ,Nahara Vargas Maldonado ,Mahnaz Minai ,Lauren McCormick ,Christopher Cole Honeycutt ,Bianca M Nagata ,Kevin W Bock ,Caitlyn N M Dulan ,Jamilet Cordon ,Dillon R Flebbe ,John-Paul M Todd ,Elizabeth McCarthy ,Laurent Pessaint ,Alex Van Ry ,Brandon Narvaez ,Daniel Valentin ,Anthony Cook ,Alan Dodson ,Katelyn Steingrebe ,Saule T Nurmukhambetova ,Sucheta Godbole ,Amy R Henry ,Farida Laboune ,Jesmine Roberts-Torres ,Cynthia G Lorang ,Shivani Amin ,Jessica Trost ,Mursal Naisan ,Manjula Basappa ,Jacquelyn Willis ,Lingshu Wang ,Wei Shi ,Nicole A Doria-Rose ,Yi Zhang ,Eun Sung Yang ,Kwanyee Leung ,Sijy O'Dell ,Stephen D Schmidt ,Adam S Olia ,Cuiping Liu ,Darcy R Harris ,Gwo-Yu Chuang ,Guillaume Stewart-Jones ,Isabella Renzi ,Yen-Ting Lai ,Agata Malinowski ,Kai Wu ,John R Mascola ,Andrea Carfi ,Peter D Kwong ,Darin K Edwards ,Mark G Lewis ,Hanne Andersen ,Kizzmekia S Corbett ,Martha C Nason ,Adrian B McDermott ,Mehul S Suthar ,Ian N Moore ,Mario Roederer ,Nancy J Sullivan ,Daniel C Douek ,Robert A Seder

Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses

既往SARS-CoV-2感染与加强疫苗接种之间的时间间隔会影响抗体和B细胞反应的强度和质量。

Clarisa M Buckner ,Lela Kardava ,Omar El Merhebi ,Sandeep R Narpala ,Leonid Serebryannyy ,Bob C Lin ,Wei Wang ,Xiaozhen Zhang ,Felipe Lopes de Assis ,Sophie E M Kelly ,I-Ting Teng ,Genevieve E McCormack ,Lauren H Praiss ,Catherine A Seamon ,M Ali Rai ,Heather Kalish ,Peter D Kwong ,Michael A Proschan ,Adrian B McDermott ,Anthony S Fauci ,Tae-Wook Chun ,Susan Moir

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine

融合前稳定的 RSV F 亚单位疫苗比融合后 F 疫苗引发的 B 细胞反应更广泛、效力更强

Lauren A Chang, Emily Phung, Michelle C Crank, Kaitlyn M Morabito, Tonya Villafana, Filip Dubovsky, Judith Falloon, Mark T Esser, Bob C Lin, Grace L Chen, Barney S Graham, Tracy J Ruckwardt