日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective and Potent PROTAC Degraders of c-Src Kinase

选择性强效的c-Src激酶PROTAC降解剂

Mao, Wuxiang; Vandecan, Nathalie M; Bingham, Christopher R; Tsang, Pui Ki; Ulintz, Peter; Sexton, Rachel; Bochar, Daniel A; Merajver, Sofia D; Soellner, Matthew B

Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase

Abl酪氨酸激酶变构抑制剂与活性位点抑制剂之间的协同作用和拮抗作用

Johnson, Taylor K; Bochar, Daniel A; Vandecan, Nathalie M; Furtado, Jessica; Agius, Michael P; Phadke, Sameer; Soellner, Matthew B

Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death

过度磷酸化使 Tau 易于聚集并导致细胞死亡

Mengyu Liu, Dexin Sui, Thomas Dexheimer, Stacy Hovde, Xiexiong Deng, Kuang-Wei Wang, Hsin Lian Lin, Hsiao-Tien Chien, Hye Kyong Kweon, Nora Sheen Kuo, Christopher A Ayoub, Daniela Jimenez-Harrison, Philip C Andrews, Roland Kwok, Daniel A Bochar, Jeff Kuret, Jessica Fortin, Yeou-Guang Tsay, Min-Hao K

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions

过度磷酸化的 tau 聚集和细胞毒性调节剂筛查出与阿尔茨海默病和认知功能相关的处方药

Mengyu Liu, Thomas Dexheimer, Dexin Sui, Stacy Hovde, Xiexiong Deng, Roland Kwok, Daniel A Bochar, Min-Hao Kuo

Functional interplay between histone demethylase and deacetylase enzymes

组蛋白去甲基化酶和去乙酰化酶之间的功能相互作用

Min Gyu Lee, Christopher Wynder, Daniel A Bochar, Mohamed-Ali Hakimi, Neil Cooch, Ramin Shiekhattar

Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase

底物诱导的三元复合物结构中瓣状结构域的闭合,为深入了解3-羟基-3-甲基戊二酰辅酶A还原酶的催化机制提供了重要线索。

Tabernero, L; Bochar, D A; Rodwell, V W; Stauffacher, C V