日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo designed proteins neutralize lethal snake venom toxins

从头设计的蛋白质能够中和致命的蛇毒毒素

Vázquez Torres, Susana; Benard Valle, Melisa; Mackessy, Stephen P; Menzies, Stefanie K; Casewell, Nicholas R; Ahmadi, Shirin; Burlet, Nick J; Muratspahić, Edin; Sappington, Isaac; Overath, Max D; Rivera-de-Torre, Esperanza; Ledergerber, Jann; Laustsen, Andreas H; Boddum, Kim; Bera, Asim K; Kang, Alex; Brackenbrough, Evans; Cardoso, Iara A; Crittenden, Edouard P; Edge, Rebecca J; Decarreau, Justin; Ragotte, Robert J; Pillai, Arvind S; Abedi, Mohamad; Han, Hannah L; Gerben, Stacey R; Murray, Analisa; Skotheim, Rebecca; Stuart, Lynda; Stewart, Lance; Fryer, Thomas J A; Jenkins, Timothy P; Baker, David

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

用于治疗眼镜蛇、曼巴蛇和环颈蛇咬伤的基于纳米抗体的重组抗蛇毒血清

Ahmadi, Shirin; Burlet, Nick J; Benard-Valle, Melisa; Guadarrama-Martínez, Alid; Kerwin, Samuel; Cardoso, Iara A; Marriott, Amy E; Edge, Rebecca J; Crittenden, Edouard; Neri-Castro, Edgar; Fernandez-Quintero, Monica L; Nguyen, Giang T T; O'Brien, Carol; Wouters, Yessica; Kalogeropoulos, Konstantinos; Thumtecho, Suthimon; Ebersole, Tasja Wainani; Dahl, Camilla Holst; Glegg-Sørensen, Emily U; Jansen, Tom; Boddum, Kim; Manousaki, Evangelia; Rivera-de-Torre, Esperanza; Ward, Andrew B; Morth, J Preben; Alagón, Alejandro; Mackessy, Stephen P; Ainsworth, Stuart; Menzies, Stefanie K; Casewell, Nicholas R; Jenkins, Timothy P; Ljungars, Anne; Laustsen, Andreas H

Discovery of broadly neutralizing V(H)Hs against short-chain α-neurotoxins using a consensus toxin as an antigen.

利用共识毒素作为抗原,发现了对短链α-神经毒素具有广泛中和作用的V(H)H

Damsbo Anna, Benard-Valle Melisa, Jansen Tom, Burlet Nick J, Overath Max D, Guadarrama-Martínez Alid, Boddum Kim, Alagon Alejandro, Rivera-de-Torre Esperanza, Laustsen Andreas H

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V(H)Hs discovered using a consensus antigen

利用共识抗原发现,广谱中和V(H)Hs能够中和长链α-神经毒素的结构机制

Damsbo, Anna; Burlet, Nick J; Fernández-Quintero, Monica L; Benard-Valle, Melisa; Overath, Max D; Guadarrama-Martínez, Alid; Vlamynck, Anneline; Bisbo, Ida; Villalobos, Cesar; Tulika, Tulika; Alagón, Alejandro; Loeffler, Johannes R; Ward, Andrew B; Boddum, Kim; Morth, Jens Preben; Rivera-de-Torre, Esperanza; Laustsen, Andreas H

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

在小鼠攻击模型中使用寡克隆纳米抗体混合物对珊瑚蛇毒进行体内中和

Melisa Benard-Valle, Yessica Wouters, Anne Ljungars, Giang Thi Tuyet Nguyen, Shirin Ahmadi, Tasja Wainani Ebersole, Camilla Holst Dahl, Alid Guadarrama-Martínez, Frederikke Jeppesen, Helena Eriksen, Gibran Rodríguez-Barrera, Kim Boddum, Timothy Patrick Jenkins, Sara Petersen Bjørn, Sanne Schoffelen,

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

针对蛇类长链α神经毒素的广谱中和人源单克隆抗体的研发与优化

Line Ledsgaard, Jack Wade, Timothy P Jenkins, Kim Boddum, Irina Oganesyan, Julian A Harrison, Pedro Villar, Rachael A Leah, Renato Zenobi, Sanne Schoffelen, Bjørn Voldborg, Anne Ljungars, John McCafferty, Bruno Lomonte, José M Gutiérrez, Andreas H Laustsen, Aneesh Karatt-Vellatt

From squid giant axon to automated patch-clamp: electrophysiology in venom and antivenom research

从鱿鱼巨轴突到自动化膜片钳:毒液和抗毒血清研究中的电生理学

Ahmadi, Shirin; Benard-Valle, Melisa; Boddum, Kim; Cardoso, Fernanda C; King, Glenn F; Laustsen, Andreas Hougaard; Ljungars, Anne

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom

体外发现可中和眼镜蛇毒致死性的人类单克隆抗体

Line Ledsgaard, Andreas H Laustsen, Urska Pus, Jack Wade, Pedro Villar, Kim Boddum, Peter Slavny, Edward W Masters, Ana S Arias, Saioa Oscoz, Daniel T Griffiths, Alice M Luther, Majken Lindholm, Rachael A Leah, Marie Sofie Møller, Hanif Ali, John McCafferty, Bruno Lomonte, José M Gutiérrez, Aneesh K

Synthetic antibodies block receptor binding and current-inhibiting effects of α-cobratoxin from Naja kaouthia

合成抗体阻断 Naja kaouthia 中的 α-眼镜蛇毒素的受体结合和电流抑制作用

Shane Miersch, Guillermo de la Rosa, Rasmus Friis, Line Ledsgaard, Kim Boddum, Andreas H Laustsen, Sachdev S Sidhu

Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes

生成基于多价纳米抗体的蛋白质,以改善对眼镜蛇长链 α 神经毒素的中和作用

Jack Wade, Charlotte Rimbault, Hanif Ali, Line Ledsgaard, Esperanza Rivera-de-Torre, Maher Abou Hachem, Kim Boddum, Nadia Mirza, Markus-Frederik Bohn, Siri A Sakya, Fulgencio Ruso-Julve, Jan Terje Andersen, Andreas H Laustsen