日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)

利用基于知识库的小分子化合物库筛选脯氨酸生物合成酶 1-吡咯啉-5-羧酸酯 1 (PYCR1)

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.5072
Meeks, Kaylen R; Bogner, Alexandra N; Tanner, John J
CR1
PYC
发表日期：2024
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Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

双功能脯氨酸分解代谢酶的晶体学片段筛选揭示了脯氨酸脱氢酶和L-谷氨酸-γ-半醛脱氢酶的新抑制剂模板

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules29225408
Meeks, Kaylen R; Bogner, Alexandra N; Nix, Jay C; Tanner, John J
代谢
发表日期：2024
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Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of N-Propargylglycine

N-丙炔甘氨酸类似物对脯氨酸脱氢酶的非共价抑制和共价失活

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.4c00429
Tanner, John J; Ji, Juan; Bogner, Alexandra N; Scott, Gary K; Patel, Sagar M; Seravalli, Javier; Gates, Kent S; Benz, Christopher C; Becker, Donald F
发表日期：2024
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Structure-based engineering of minimal proline dehydrogenase domains for inhibitor discovery

基于结构的最小脯氨酸脱氢酶结构域工程改造用于抑制剂发现

期刊:Protein Engineering Design & Selection
影响因子:3.4
doi:10.1093/protein/gzac016
Bogner, Alexandra N; Ji, Juan; Tanner, John J
发表日期：2022
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Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline.

反式-4-羟基-L-脯氨酸对双脯氨酸/羟脯氨酸分解代谢酶ALDH4A1立体选择性抑制的结构基础

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.4131
Bogner Alexandra N, Stiers Kyle M, McKay Cole M, Becker Donald F, Tanner John J
代谢
H4
发表日期：2021
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Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles

S-杂环化合物对脯氨酸脱氢酶的光诱导共价不可逆失活

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.1c00427
Campbell, Ashley C; Prater, Austin R; Bogner, Alexandra N; Quinn, Thomas P; Gates, Kent S; Becker, Donald F; Tanner, John J
发表日期：2021
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Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-γ-semialdehyde dehydrogenase active site of bifunctional proline utilization A.

双功能脯氨酸利用酶A中脯氨酸和羟脯氨酸与l-谷氨酸-γ-半醛脱氢酶活性位点结合的结构分析

期刊:Archives of Biochemistry and Biophysics
影响因子:3
doi:10.1016/j.abb.2020.108727
Campbell Ashley C, Bogner Alexandra N, Mao Yizi, Becker Donald F, Tanner John J
免疫/内分泌
发表日期：2021
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Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target

脯氨酸生物合成酶吡咯啉-5-羧酸还原酶 (PYCR) 的结构、生物化学和基因表达模式，一种新兴的癌症治疗靶点

期刊:Amino Acids
影响因子:2.4
doi:10.1007/s00726-021-02999-5
Bogner, Alexandra N; Stiers, Kyle M; Tanner, John J
肿瘤
PYC
肿瘤免疫
发表日期：2021
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