日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage

NAD补充剂在治疗伴有早衰和DNA损伤的罕见疾病方面展现出令人鼓舞的成果

Bohr, Vilhelm A

Novel roles of DNA glycosylases in neurodegenerative diseases and aging

DNA糖基化酶在神经退行性疾病和衰老中的新作用

Tiwari, Vinod; Borbolis, Fivos; Croteau, Deborah L; Palikaras, Konstantinos; Bohr, Vilhelm A

Selective interactions at pre-replication complexes categorize baseline and dormant origins.

复制前复合物的选择性相互作用将基础复制起点和休眠复制起点分类

Thakur Bhushan L, Redon Christophe E, Fu Haiqing, Sebastian Robin, Kusi Nana A, Zhuang Sophie Z, Pongor Lorinc S, Bohr Vilhelm A, Aladjem Mirit I

Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis.

科凯恩综合征小鼠反映了人类肾脏疾病,并且在从头合成 NAD 方面存在缺陷。

Pekhale Komal, Tiwari Vinod, Hussain Mansoor, Bridges Christy C, Croteau Deborah L, Levi Moshe, Rosenberg Avi Z, Santo Briana, Yang Xiaoping, Kulikowicz Tomasz, Wang Xiaoxin X, Lee Jong-Hyuk, Bohr Vilhelm A

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial

烟酰胺核苷补充剂对沃纳综合征患者的益处:一项双盲随机交叉安慰剂对照试验

Shoji, Mayumi; Kato, Hisaya; Koshizaka, Masaya; Kaneko, Hiyori; Baba, Yusuke; Ishikawa, Takahiro; Teramoto, Naoya; Kinoshita, Daisuke; Yamaguchi, Ayano; Maeda, Yukari; Inaba, Yosuke; Shiko, Yuki; Ozawa, Yoshihito; Bohr, Vilhelm A; Maezawa, Yoshiro; Yokote, Koutaro

Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin

空间转录组学揭示了tau蛋白及其病理对转甲状腺素蛋白表达的意外影响

Croteau, Deborah L; Navarro, Jose Fernandez; Comptdaer, Thomas; Andrusivova, Zaneta; Jurek, Aleksandra; Bonnefoy, Eliette; Buée, Luc; Bohr, Vilhelm A; Lundeberg, Joakim; Galas, Marie-Christine

Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies

社论:靶向衰老线粒体:机制、方法和治疗策略

Li, Zhiquan; Palikaras, Konstantinos; Li, Yuan; Bohr, Vilhelm A

Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair-Deficient 3xTg/POLβ(+/-) Alzheimer Disease Mouse Model

饮食酮症和烟酰胺核苷对DNA修复缺陷型3xTg/POLβ(+/-)阿尔茨海默病小鼠模型海马克雷布斯循环中间体和线粒体能量学的影响

Pawlosky, Robert; Demarest, Tyler G; King, M Todd; Estrada, Darlene; Veech, Richard L; Bohr, Vilhelm A

Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation.

WRN 缺陷细胞中线粒体 NAD+ 减少与增殖功能障碍有关

Lautrup Sofie, Zhang Shi-Qi, Funayama Shinichiro, Lirussi Lisa, Visnovska Tina, Cheung Hoi-Hung, Niere Marc, Tian Yuyao, Nilsen Hilde Loge, Selbæk Geir, Saarela Janna, Maezawa Yoshiro, Yokote Koutaro, Nilsson Per, Chan Wai-Yee, Kato Hisaya, Ziegler Mathias, Bohr Vilhelm A, Fang Evandro F

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease

线粒体积聚和溶酶体功能障碍会导致阿尔茨海默病中出现线粒体斑块。

Dan, Xiuli; Croteau, Deborah L; Liu, Wenlong; Chu, Xixia; Robbins, Paul D; Bohr, Vilhelm A