日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Using the Simcyp R Package for PBPK Simulation Workflows With the Simcyp Simulator

使用 Simcyp R 包和 Simcyp 模拟器进行 PBPK 模拟工作流程

Onasanwo, Anthonia M; Mittapelly, Naresh; Shireman, Laura; Vinden, Barry; McNally, Kevin; Craig, James; Bois, Frederic Y

Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.

利用高通量转录组学和来自 50 位供体的原代人肝细胞绘制毒物动力学个体间差异图谱

Niemeijer Marije, Więcek Witold, Fu Shuai, Huppelschoten Suzanna, Bouwman Peter, Baze Audrey, Parmentier Céline, Richert Lysiane, Paules Richard S, Bois Frederic Y, van de Water Bob

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework

在生理药代动力学框架下评估胆固醇代谢产物4β-羟基胆固醇作为肝脏CYP3A活性敏感内源性生物标志物的应用

Karkhanis, Aneesh V; Harwood, Matthew D; Stader, Felix; Bois, Frederic Y; Neuhoff, Sibylle

A Bayesian framework for virtual comparative trials and bioequivalence assessments

基于贝叶斯框架的虚拟比较试验和生物等效性评价

Bois, Frederic Y; Brochot, Céline

A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator

Simcyp模拟器中基于生理的药代动力学建模的人群文件开发指南

Curry, Liam; Alrubia, Sarah; Bois, Frederic Y; Clayton, Ruth; El-Khateeb, Eman; Johnson, Trevor N; Faisal, Muhammad; Neuhoff, Sibylle; Wragg, Kris; Rostami-Hodjegan, Amin

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn's Disease Patients through PBPK Modeling

通过PBPK模型了解布地奈德在健康人和克罗恩病患者体内体外溶出度、局部肠道和全身生物等效性之间的差异

Han, Chunyan; Sun, Tiancheng; Chirumamilla, Siri Kalyan; Bois, Frederic Y; Xu, Mandy; Rostami-Hodjegan, Amin

Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

应用循证方法构建机制驱动的化学品评估框架

Hoffmann, Sebastian; Aiassa, Elisa; Angrish, Michelle; Beausoleil, Claire; Bois, Frederic Y; Ciccolallo, Laura; Craig, Peter S; De Vries, Rob B M; Dorne, Jean Lou C M; Druwe, Ingrid L; Edwards, Stephen W; Eskes, Chantra; Georgiadis, Marios; Hartung, Thomas; Kienzler, Aude; Kristjansson, Elisabeth A; Lam, Juleen; Martino, Laura; Meek, Bette; Morgan, Rebecca L; Munoz-Guajardo, Irene; Noyes, Pamela D; Parmelli, Elena; Piersma, Aldert; Rooney, Andrew; Sena, Emily; Sullivan, Kristie; Tarazona, José; Terron, Andrea; Thayer, Kris; Turner, Jan; Verbeek, Jos; Verloo, Didier; Vinken, Mathieu; Watford, Sean; Whaley, Paul; Wikoff, Daniele; Willett, Kate; Tsaioun, Katya

Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers

使用 Simcyp 模拟器的参数和非参数方法以及贝叶斯抽样器进行群体 PBPK 建模

Wedagedera, Janak R; Afuape, Anthonia; Chirumamilla, Siri Kalyan; Momiji, Hiroshi; Leary, Robert; Dunlavey, Mike; Matthews, Richard; Abduljalil, Khaled; Jamei, Masoud; Bois, Frederic Y

Opening a debate on open-source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

就开源建模工具展开辩论:是火上浇油还是扼杀一场健康的辩论之火

Rostami-Hodjegan, Amin; Bois, Frederic Y

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

将全局敏感性分析方法应用于基于生理的药代动力学模型时需要考虑的因素和注意事项

Liu, Dan; Li, Linzhong; Rostami-Hodjegan, Amin; Bois, Frederic Y; Jamei, Masoud