Boldogh Istvan相关文献与解析，生知库 | 链接生命科学的每一步

Lactate as a metabolic-epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome.

乳酸作为一种代谢表观遗传信号，将高强度间歇训练 (HIIT) 与以 miRNA 为中心的骨骼肌甲基化组和转录组重塑联系起来。

doi:10.1016/j.redox.2025.103943

Zhou Lei, Mozaffaritabar Soroosh, Tanisawa Kumpei, Kawamura Takuji, Higuchi Mitsuru, Boldogh Istvan, Ba Xueqing, Goto Sataro, Brooks George, Gu Yaodong, RadÃ¡k Zsolt

OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate

OGG1S326C 变异体在人类群体中常见，由于其与 DNA 底物的相互作用增强，可促进炎症反应。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2426102122

Han, Jinling; Zhang, Meichen; Ge, Jiakun; Ji, Zhihua; Zhao, Jianyi; Hu, Yinchao; Li, Chunshuang; Xue, Yaoyao; Li, Xining; Zhao, Haiwang; Cui, Zixu; Tian, Miaomiao; Zheng, Xu; Wang, Dapeng; Wang, Jing; Wei, Min; Radak, Zsolt; Nakabeppu, Yusaku; Boldogh, Istvan; Ba, Xueqing

OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation.

OGG1 增强 Foxp3 的转录激活，促进 iTreg 分化，从而缓解 IBD

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2424733122

Tian Miaomiao, Hao Fengqi, Wang Xinyu, Zheng Xu, Wang Huiyue, Li Jing, Li Zilin, Xia Mingjie, Li Changfeng, Zhao Zhexuan, Han Jinling, Li Dan, Nakabeppu Yusaku, Boldogh Istvan, Wei Min, Ba Xueqing

Tom40 functions as a channel for protein retrotranslocation in the mitochondria-associated degradation (MAD) pathway.

Tom40 在线粒体相关降解 (MAD) 途径中作为蛋白质逆向转运的通道发挥作用

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-025-08549-z

Liao Pin-Chao, Lin Tzu-Ying, Tsang Catherine A, Huang Chen-Jing, Filpo Katherine, Boldogh Istvan, Pon Liza A

Inhibition by 4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide (TH5487) of the Activity of Human 8-Oxoguanine DNA Glycosylase-1 (OGG1) for the Excision of 2,6-Diamino-4-hydroxy-5-formamidopyrimidine, 4,6-Diamino-5-formamidopyrimidine, and 8-Oxoguanine from Oxidatively Damaged DNA

4-(4-溴-2-氧代-3H-苯并咪唑-1-基)-N-(4-碘苯基)哌啶-1-甲酰胺 (TH5487) 对人 8-氧鸟嘌呤 DNA 糖基化酶-1 (OGG1) 从氧化损伤 DNA 中切除 2,6-二氨基-4-羟基-5-甲酰胺基嘧啶、4,6-二氨基-5-甲酰胺基嘧啶和 8-氧鸟嘌呤的活性具有抑制作用

期刊:Biochemistry

影响因子:3

doi:10.1021/acs.biochem.4c00419

Jaruga, Pawel; Kant, Melis; Luzadder, Michael M; Lloyd, R Stephen; Boldogh, Istvan; Dizdaroglu, Miral

The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases

OGG1抑制剂有望成为肺部疾病的治疗策略

期刊:Expert Opinion on Therapeutic Targets

影响因子:4.4

doi:10.1080/14728222.2024.2317900

Pan, Lang; Boldogh, Istvan

OGG1

发表日期：2024

文献求助收藏

Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

更正：哺乳动物DNA末端加工酶多核苷酸激酶3'-磷酸酶在脊髓小脑性共济失调3型发病机制中的作用

期刊:PLoS Genetics

影响因子:3.7

doi:10.1371/journal.pgen.1011124

Chatterjee, Arpita; Saha, Saikat; Chakraborty, Anirban; Silva-Fernandes, Anabela; Mandal, Santi M; Neves-Carvalho, Andreia; Liu, Yongping; Pandita, Raj K; Hegde, Muralidhar L; Hegde, Pavana M; Boldogh, Istvan; Ashizawa, Tetsuo; Koeppen, Arnulf H; Pandita, Tej K; Maciel, Patricia; Sarkar, Partha S; Hazra, Tapas K

8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury

8-氧鸟嘌呤是8-氧鸟嘌呤DNA糖基化酶1 (OGG1) 的靶标，在肺损伤后纤维化基因的激活中起着核心作用。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkac1241

Pan, Lang; Hao, Wenjing; Xue, Yaoyao; Wang, Ke; Zheng, Xu; Luo, Jixian; Ba, Xueqing; Xiang, Yang; Qin, Xiaoqun; Bergwik, Jesper; Tanner, Lloyd; Egesten, Arne; Brasier, Allan R; Boldogh, Istvan

OGG1

发表日期：2023

文献求助收藏

Physical Fitness Is Negatively Associated With DNA Methylation-Based Risk of Aging-Related Diseases

身体素质与基于DNA甲基化的衰老相关疾病风险呈负相关

Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis

重新评估氧化性DNA碱基损伤8-oxoGua和修复酶OGG1在肿瘤发生中的作用

Lactate as a metabolic-epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome.

乳酸作为一种代谢表观遗传信号，将高强度间歇训练 (HIIT) 与以 miRNA 为中心的骨骼肌甲基化组和转录组重塑联系起来。

OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate

OGG1S326C 变异体在人类群体中常见，由于其与 DNA 底物的相互作用增强，可促进炎症反应。

OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation.

OGG1 增强 Foxp3 的转录激活，促进 iTreg 分化，从而缓解 IBD

Tom40 functions as a channel for protein retrotranslocation in the mitochondria-associated degradation (MAD) pathway.

Tom40 在线粒体相关降解 (MAD) 途径中作为蛋白质逆向转运的通道发挥作用

4-(4-溴-2-氧代-3H-苯并咪唑-1-基)-N-(4-碘苯基)哌啶-1-甲酰胺 (TH5487) 对人 8-氧鸟嘌呤 DNA 糖基化酶-1 (OGG1) 从氧化损伤 DNA 中切除 2,6-二氨基-4-羟基-5-甲酰胺基嘧啶、4,6-二氨基-5-甲酰胺基嘧啶和 8-氧鸟嘌呤的活性具有抑制作用

The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases

OGG1抑制剂有望成为肺部疾病的治疗策略

Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

更正：哺乳动物DNA末端加工酶多核苷酸激酶3'-磷酸酶在脊髓小脑性共济失调3型发病机制中的作用

8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury

8-氧鸟嘌呤是8-氧鸟嘌呤DNA糖基化酶1 (OGG1) 的靶标，在肺损伤后纤维化基因的激活中起着核心作用。